Abstract
Introductory biology textbooks often use the example of sickle-cell anemia to illustrate the concept of heterozygote protection. Ordinarily scientists expect the frequency of a gene associated with a debilitating illness would be low owing to its continual elimination by natural selection. The gene that causes sickle-cell anemia, however, has a relatively high frequency in many parts of the world. Historically, scientists proposed and defended several alternative theories to account for this anomaly, though it is now widely recognized among the scientific community that high frequencies of the gene reflect its benefit to heterozygotes against malaria. Textbooks normally develop this concept with reference to the often-used maps of Africa showing how in areas where the frequency of the sickle-cell gene is high, there is also higher exposure to the disease malaria. While sickle-cell anemia is often the example of choice for explaining and illustrating the concept of heterozygote protection, the present paper argues that exploring the history of scientific research behind our contemporary understanding has advantages for helping students understand multiple factors related to population genetics (e.g. mutation, gene flow, drift) in addition to heterozygote protection. In so doing, this approach invites students to evaluate the legitimacy of their own alternative conceptions about introductory population genetics or about the genetics of the disease sickle-cell anemia. The various historical theories scientists proposed and defended often resemble those of students who first learn about the disease. As such, a discussion of how scientists reached consensus about the role of heterozygote protection may help students understand and appreciate what are now recognized to be limitations in the views they bring to their classrooms. The paper concludes by discussing the ramifications of this approach in potentially helping students to examine certain aspects of the nature of science.
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References
F. Abd-El-Khalick N. Lederman (2000) ArticleTitle‘‘The Influence of History of Science Courses on Students’ Views of Nature of Science’’ Journal of Research in Science Teaching 37 IssueID10 1057–1095 Occurrence Handle10.1002/1098-2736(200012)37:10<1057::AID-TEA3>3.0.CO;2-C
V.L. Akerson F. Abd-El-Khalick N. Lederman (2000) ArticleTitle‘Influence of a Reflective Explicit Activity-based Approach on Elementary Teachers’ Conceptions of the Nature of Science’ Journal of Research in Science Teaching 37 IssueID4 295–317 Occurrence Handle10.1002/(SICI)1098-2736(200004)37:4<295::AID-TEA2>3.0.CO;2-2
C. Albaladejo A. Lucas (1988) ArticleTitle‘Pupil’s Meanings for Mutation’ Journal of Biological Education 22 IssueID3 215–219
D. Allchin (1997) ArticleTitle‘Rekindling Phlogiston: From Classroom Case Study to Interdisciplinary Relationships’ Science and Education 6 IssueID5 473–509 Occurrence Handle10.1023/A:1008640314559
Allison, A.C.: January, 2001, Personal Communication, Palo Alto, California.
A.C. Allison (1954a) ArticleTitle‘Protection by the Sickle Cell Trait Against Subtertian Malarial Infection’ British Medical Journal 1 290–292
A.C. Allison (1954b) ArticleTitle‘The Distribution of the Sickle Cell Trait in East Africa and Elsewhere and its Apparent Relationship to the Incidence of Subtertian Malaria’ Transactions of the Royal Society of Tropical Medicine and Hygiene 48 312–318 Occurrence Handle10.1016/0035-9203(54)90101-7
A.C. Allison (1968) Genetics and Infectious Disease K.R. Dronamraju (Eds) Haldane and Modern Biology The Johns Hopkins Press Baltimore 179–201
E. Beet (1946) ArticleTitle‘Sickle-cell Disease in the Balovale District of Northern Rhodesia’ East African Medical Journal 23 75–86
E. Beet (1947) ArticleTitle‘Sickle-cell Disease in Northern Rhodesia’ East African Medical Journal 24 212–222
E. Beet (1949) ArticleTitle‘The Genetics of a Sickle-cell Trait in a Bantu Tribe’ Annals of Eugenics, London 14 279–284
M.E. Beeth P.W. Hewson (1999) ArticleTitle‘Learning Goals in an Exemplary Science Teacher’s Practice: Cognitive and Social Factors in Teaching for Conceptual Change’ Science Education 83 IssueID6 738–760 Occurrence Handle10.1002/(SICI)1098-237X(199911)83:6<738::AID-SCE6>3.0.CO;2-9
P. Brain (1952) ArticleTitle‘The Sickle Cell Trait: It’s Clinical Significance’ South African Medical Journal 26 IssueID47 925–928
M. Cain H. Damman R. Lue C. Yoon (2000) Discover Biology W.W. Norton and Company New York
J.L. Cartier J. Stewart (2000) ArticleTitle‘Teaching the Nature of Inquiry: Further Developments in a High School Genetics Curriculum’ Science and Education 9 IssueID3 247–267 Occurrence Handle10.1023/A:1008779126718
L.L. Cavalli-Sworza W.F. Bodner (1971 (1999)) The Genetics of Human Populations Dover Publications New York
H. Cho J.B. Kahle F.H. Norland (1985) ArticleTitle‘An Investigation of High School Biology Textbooks as Sources of Misconceptions and Difficulties in Genetics and Some Suggestions for Teaching Genetics’ Science Education 69 IssueID5 707–719 Occurrence Handle10.1002/sce.3730690512
M.R. Cummings (2003) Human Heredity: Principles and Issues EditionNumber6 Thompson Australia
N. Eldredge (1985) Unfinished Synthesis. Biological Hierarchies and Modern Evolutionary Thought Oxford University Press New York
Fisher, R.A.: 1930, The Genetical Theory of Natural Selection, Oxford University Press, Oxford
E.B. Ford (1940) Genetics for Medical Students Methuen London
H. Foy A. Kondi (1951) ArticleTitle‘Sickle-cell Anemia in Africans’ Lancet 2 451–452 Occurrence Handle10.1016/S0140-6736(51)91719-9
H. Foy A. Kondi (1954) ArticleTitle‘The Variability of Sickle-cell Rates in the Tribes of Kenya and the Southern Sudan’ British Medical Journal 1 294–297
J.B.S. Haldane (1935) ArticleTitle‘The Rate of Spontaneous Mutation of a Human Gene’ Journal of Genetics 31 317–326 Occurrence Handle10.1007/BF02982403
J.B.S. Haldane (1949) ArticleTitle‘Disease and Evolution’ La Ricerca Scientifica 19 IssueIDSupplement 68–76
W.G. Heim (1991) ArticleTitle‘What Is a Recessive Allele?’ The American Biology Teacher 53 IssueID2 94–97
A. Herrick (1968) Area Handbook for Uganda U.S. Government Printing Office Washington, D.C
E.M. Howe D.W. Rudge (2005) ArticleTitle‘Recapitulating the History of Sickle-Cell Anemia Research: Improving Students’ NOS Views Explicitly and Reflectively’ Science and Education 14 IssueID3–5 423–441
Howe, E.: 2004, Using the History of Research on Sickle-Cell Anemia to Affect Preservice Teachers’ Conceptions of the Nature of Science, Unpublished doctoral dissertation, Western Michigan University, Kalamazoo, Michigan
R. Khishfe F. Abd-El-Khalick (2002) ArticleTitle‘Influence of Explicit and Reflective Versus Implicit Inquiry-Oriented Instruction on Sixth Graders’ Views of Nature of Science’ Journal of Research in Science Teaching 7 IssueID39 551–578 Occurrence Handle10.1002/tea.10036
B. Latour S. Woolgar (1979) Laboratory Life: The Social Construction of Scientific Facts Sage Publications Beverly Hills, CA
H. Lehmann A. Raper (1949) ArticleTitle‘Distribution of the Sickle-cell Trait in Uganda, and Its Ethnological Significance’ Nature, London 164 494–495
H. Lehmann (1953) ArticleTitle‘Distribution of the Sickle-cell Gene’ Eugenics Review 46 101–121
J.V. Neel (1949) ArticleTitle‘The Inheritance of Sickle-cell Anemia’ Science 110 164–166 Occurrence Handle10.1126/science.110.2846.64
J.V. Neel (1952) ArticleTitle‘Perspectives in the Genetics of Sickle-cell Disease’ Blood 7 467–471
L. Pauling H. Itano S. Singer I. Wells (1949) ArticleTitle‘Sickle-cell Anemia, a Molecular Disease’ Science 110 543–547 Occurrence Handle10.1126/science.110.2865.543
G. Posner K. Strike P. Hewson W. Gertzog (1982) ArticleTitle‘Accommodation of a Scientific Conception: Toward a Theory of Conceptual Change’ Science Education 66 IssueID2 211–227 Occurrence Handle10.1002/sce.3730660207
Provine, W.B.: 1971 (2000), The Origins of Theoretical Population Genetics, University of Chicago Press, Chicago.
A. Raper (1950) ArticleTitle‘Sickle-cell Disease in Africa and America – A Comparison’ Journal of Tropical Medicine 53 49–53
A. Raper (1956) ArticleTitle‘Sickling in Relation to Morbidity from Malaria and Other Diseases’ British Medical Journal i 965–967 Occurrence Handle10.1136/bmj.1.4973.965
A. Raper (1959) ArticleTitle‘Further Observations on Sickling and Malaria’ Transactions of the Royal Society of Tropical Medicine and Hygiene 53 110–117 Occurrence Handle10.1016/0035-9203(59)90093-8
D.W. Rudge E.M. Howe (2004) ArticleTitle‘Incorporating History into the Science Classroom’ The Science Teacher 71 IssueID9 52–57
D.W. Rudge (2000) ArticleTitle‘Does Being Wrong Make Kettlewell Wrong for Science Teaching?’ Journal of Biological Education 35 IssueID1 5–11
P. Russell (1986) Genetics Little, Brown and Company Boston
K. Strike G. Posner (1992) A Revisionist Theory of Conceptual Change R. Duschl R. Hamilton (Eds) Philosophy of Science, Cognitive Psychology, and Educational Theory and Practice State University of New York Press Albany 147–176
W. Taliaferro J. Huck (1923) ArticleTitle‘The Inheritance of Sickle Cell Anemia in Man’ Genetics 8 594–598
K. Wailoo (1997) Drawing Blood: Technology and Disease Identity in Twentieth-Century America The John Hopkins University Press Baltimore
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Howe, E.M. ‘Untangling Sickle-cell Anemia and the Teaching of Heterozygote Protection’. Sci Educ 16, 1–19 (2007). https://doi.org/10.1007/s11191-005-4712-7
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DOI: https://doi.org/10.1007/s11191-005-4712-7