Summary
The rate of mutation at which the gene for haemophilia appears in the population of London is estimated at about once in 50,000 human life cycles. There are probably two distinct allelomorphs at the same locus, the milder type arising less frequently by mutation than the severe type.
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References
Bulloch, W. andFildes, P. (1912).Treasury of Human Inheritance,1, 169.
Cockayne, E. A. (1933).Inherited Abnormalities of the Skin and Appendages. Oxford.
Davenport, C. B. (1930). “Sex linkage in man.”Genetics,15, 401.
Haldane, J. B. S. (1927). “A mathematical theory of natural and artificial selection. Part V.”Proc. Camb. phil. Soc. 23, 838.
Hogben, L. T. (1931).Genetic Principles in Medicine and Social Science. London.
Komai, T. (1934).Pedigrees of Hereditary Diseases and Abnormalities found in the Japanese Race. Kyoto.
Manson, J. S. (1928).Observations on Human Heredity. London.
Muller, H. J. (1928). “The measurement of gene mutation rate inDrosophila, its high variability, and its dependence upon temperature.”Genetics,13, 279.
Patterson, J. T. andMuller, H. J. (1930). “Are ‘progressive’ mutations produced by X-rays?” Ibid.15, 495.
Penrose, L. S. (1934).The Influence of Heredity on Disease. London.
Stadler, L. J. (1932). “On the genetic nature of induced mutations in plants.”Proc. 6th Int. Cong. Genet. Menasha, Wis.
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Haldane, J.B.S. The rate of spontaneous mutation of a human gene. Journ. of Genetics 31, 317–326 (1935). https://doi.org/10.1007/BF02982403
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DOI: https://doi.org/10.1007/BF02982403