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Synthesis of 3,4-dihydroisoquinolines using nitroalkanes in polyphosphoric acid

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Abstract

A new method for the synthesis of 6,7-dimethoxy-3,4-dihydroisoquinoline based on the reaction of 2-(3,4-dimethoxyphenyl)ethan-1-amine (homoveratrylamine) with aliphatic nitro compounds in polyphosphoric acid (PPA) was developed.

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Authors and Affiliations

  1. North Caucasus Federal University, 1A ul. Pushkina, 355009, Stavropol, Russian Federation

    N. A. Aksenov, V. V. Malyuga, D. A. Aksenov & A. V. Aksenov

  2. Dagestan State Technical University, 70 ul. Imama Shamilya, 367010, Makhachkala, Russian Federation

    G. M. Abakarov

  3. Peoples’ Friendship University of Russia, 6 ul. Miklukho-Maklaya, 117198, Moscow, Russian Federation

    L. G. Voskressensky

Authors
  1. N. A. Aksenov
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  2. V. V. Malyuga
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  3. G. M. Abakarov
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  4. D. A. Aksenov
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  5. L. G. Voskressensky
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Correspondence to N. A. Aksenov.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 1047–1051, May, 2019.

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Aksenov, N.A., Malyuga, V.V., Abakarov, G.M. et al. Synthesis of 3,4-dihydroisoquinolines using nitroalkanes in polyphosphoric acid. Russ Chem Bull 68, 1047–1051 (2019). https://doi.org/10.1007/s11172-019-2518-z

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  • DOI: https://doi.org/10.1007/s11172-019-2518-z

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