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Immobilized phthalocyanines of magnesium, aluminum, and zinc in photodynamic treatment of mesenchymal stromal cells

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Abstract

Phthalocyanines of magnesium, aluminum, and zinc immobilized on nano-sized silica and poly-N-vinylpyrrolidone in aqueous solutions were synthesized. Photochemical activity of the immobilized metal complexes was assessed by generation of singlet oxygen. Nontoxic concentrations of the new photosensitizers were determined in vitro. A comparative analysis of the efficiency of photodynamic therapy (PDT) was performed for immobilized phthalocyanines using mesenchymal stromal cells as a cell model. Aluminum phthalocyanine immobilized on nano-sized silica displayed the highest cell tropism. Irradiation of phthalocyanine-loaded cells resulted in generation of active singlet oxygen and subsequent apoptotic cell death. The use of immobilized phthalocyanines allowed decreasing the effective concentration (dose) of photosensitizer and enhancing the PDT cytotoxicity.

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Authors and Affiliations

  1. Institute of Biomedical Problems, Russian Academy of Sciences, 76A Khoroshevskoe shosse, 123007, Moscow, Russian Federation

    O. O. Udartseva, E. R. Andreeva & L. B. Buravkova

  2. N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, 4 ul. Kosygina, 119991, Moscow, Russian Federation

    A. V. Lobanov

  3. G. V. Plekhanov Russian University of Economics, 36 Stremyanny per., 117997, Moscow, Russian Federation

    A. V. Lobanov

  4. Department of Fundamental Medicine, M. V. Lomonosov Moscow State University, 31/5 Lomonosovskiy prosp., 119192, Moscow, Russian Federation

    L. B. Buravkova

  5. Department of Chemistry, M. V. Lomonosov Moscow State University, 1/3 Leninskie Gory, 119991, Moscow, Russian Federation

    M. Ya. Melnikov

Authors
  1. O. O. Udartseva
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  2. A. V. Lobanov
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  3. E. R. Andreeva
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  4. L. B. Buravkova
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  5. M. Ya. Melnikov
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Correspondence to A. V. Lobanov.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 0277—0281, January, 2016.

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Udartseva, O.O., Lobanov, A.V., Andreeva, E.R. et al. Immobilized phthalocyanines of magnesium, aluminum, and zinc in photodynamic treatment of mesenchymal stromal cells. Russ Chem Bull 65, 277–281 (2016). https://doi.org/10.1007/s11172-016-1297-z

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  • DOI: https://doi.org/10.1007/s11172-016-1297-z

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