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A new approach to the synthesis of ligands of asialoglycoprotein receptor for targeted delivery of oligonucleotides to hepatocytes

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Abstract

A new approach to the synthesis of organic ligands of asialoglycoprotein receptor was suggested. It was shown that the azido-containing tervalent N-acetylglucosamine and N-acetyl-mannosamine derivatives obtained by this method can serve as convenient starting compounds for the synthesis of therapeutical conjugates with oligonucleotides containing a terminal alkyne.

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Author information

Authors and Affiliations

  1. Department of Chemistry, M. V. Lomonosov Moscow State University, Build. 3, 1 Leninskie Gory, 119991, Moscow, Russian Federation

    S. Yu. Maklakova, F. A. Kucherov, R. A. Petrov, V. V. Gopko, T. S. Zatsepin, E. K. Beloglazkina, N. V. Zyk, A. G. Majouga & V. E. Koteliansky

  2. Central Research Institute of Epidemiology, 3a ul. Novogireevskaya, 111123, Moscow, Russian Federation

    G. A. Shipulin & T. S. Zatsepin

  3. Skolkovo Institute of Science and Technology, 100 ul. Novaya, 143025, Skolkovo, Russian Federation

    T. S. Zatsepin & V. E. Koteliansky

  4. National University of Science and Technology MISiS, 4 Leninsky prosp, 119991, Moscow, Russian Federation

    E. K. Beloglazkina & A. G. Majouga

Authors
  1. S. Yu. Maklakova
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  2. F. A. Kucherov
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  3. R. A. Petrov
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  4. V. V. Gopko
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  5. G. A. Shipulin
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  6. T. S. Zatsepin
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  7. E. K. Beloglazkina
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  8. N. V. Zyk
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  9. A. G. Majouga
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  10. V. E. Koteliansky
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Corresponding authors

Correspondence to E. K. Beloglazkina or A. G. Majouga.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1655–1662, July, 2015.

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Maklakova, S.Y., Kucherov, F.A., Petrov, R.A. et al. A new approach to the synthesis of ligands of asialoglycoprotein receptor for targeted delivery of oligonucleotides to hepatocytes. Russ Chem Bull 64, 1655–1662 (2015). https://doi.org/10.1007/s11172-015-1056-6

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  • DOI: https://doi.org/10.1007/s11172-015-1056-6

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