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Stabilizing effect of cholesterol on the state of β2-adrenergic receptor with a broken ionic lock: a molecular dynamics study

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Abstract

A molecular dynamics simulation of the β2-adrenergic receptor (β2AR) embedded in a hydrated lipid bilayer showed that the state with a broken ionic lock (salt bridge) between the arginine residue Arg131 and the glutamic acid residue Glu268 is stabilized in the presence of cholesterol molecules. This should be considered as a transient state to the active state of the receptor.

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Authors and Affiliations

  1. Department of Chemistry, M. V. Lomonosov Moscow State University, 1 Leninskie Gory, 119992, Moscow, Russian Federation

    E. S. Alekseev & T. V. Bogdan

Authors
  1. E. S. Alekseev
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  2. T. V. Bogdan
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Correspondence to T. V. Bogdan.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2567–2573, December, 2013.

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Alekseev, E.S., Bogdan, T.V. Stabilizing effect of cholesterol on the state of β2-adrenergic receptor with a broken ionic lock: a molecular dynamics study. Russ Chem Bull 62, 2567–2573 (2013). https://doi.org/10.1007/s11172-013-0374-9

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  • DOI: https://doi.org/10.1007/s11172-013-0374-9

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