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Synthesis of N,N′-di(tert-butyl)bispidin-9-ones

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Abstract

Condensation of 1,3,5-tri(tert-butyl)-1,3,5-triazacyclohexane with acetone gave 3,7-di(tert-butyl)-1,5-bis[(tert-butylamino)methyl]bispidin-9-one. Reactions with ethyl methyl ketone and other ketones of the formula RCH2COCH3 yielded 5-R-3,7-di(tert-butyl)-1-[(tert-butylamino)methyl]bispidin-9-ones, while reactions with diethyl ketone and other symmetrical ketones of the formula RCH2COCH2R afforded 1,5-R-3,7-di(tert-butyl)bispidin-9-ones.

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Authors and Affiliations

  1. M. V. Lomonosov Moscow State University of Fine Chemical Technologies, 86 prosp. Vernadskogo, 119571, Moscow, Russian Federation

    A. I. Kuznetsov & I. M. Senan

  2. Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation

    T. M. Serova

Authors
  1. A. I. Kuznetsov
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  2. I. M. Senan
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  3. T. M. Serova
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Correspondence to A. I. Kuznetsov.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 307–311, February, 2012.

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Kuznetsov, A.I., Senan, I.M. & Serova, T.M. Synthesis of N,N′-di(tert-butyl)bispidin-9-ones. Russ Chem Bull 61, 308–312 (2012). https://doi.org/10.1007/s11172-012-0043-4

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  • DOI: https://doi.org/10.1007/s11172-012-0043-4

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