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Formation of 1,3-diazaadamantane derivatives by the reaction of bispidine derivatives with dialdehydes

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Abstract

Heating of 3,7-di(tert-butyl)-1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-one with hydro-bromic acid gave 1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-one (1,5-dimethylbispidin-9-one). Condensation of this compound or 1,5-dimethylbispidin-9-ol with dialdehydes afforded new compounds containing two 1,3-diazaadamantane moieties in one molecule, which are connected either directly or through spacers.

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Authors and Affiliations

  1. M. V. Lomonosov Moscow State University of Fine Chemical Technologies, 86 prosp. Vernadskogo, 119571, Moscow, Russian Federation

    A. I. Kuznetsov, I. M. Senan & I. O. Razenko

  2. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 1 Severnyi pr-d, 142432 Chernogolovka, Moscow Region, Russian Federation

    T. M. Serova

Authors
  1. A. I. Kuznetsov
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  2. I. M. Senan
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  3. I. O. Razenko
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  4. T. M. Serova
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Corresponding author

Correspondence to A. I. Kuznetsov.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2689—2692, December, 2014.

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Kuznetsov, A.I., Senan, I.M., Razenko, I.O. et al. Formation of 1,3-diazaadamantane derivatives by the reaction of bispidine derivatives with dialdehydes. Russ Chem Bull 63, 2689–2692 (2014). https://doi.org/10.1007/s11172-014-0800-7

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  • DOI: https://doi.org/10.1007/s11172-014-0800-7

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