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Secondary amines immobilized inside magnetic mesoporous materials as a recyclable basic and oxidative heterogeneous nanocatalyst for the synthesis of trisubstituted pyrimidine derivatives

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Abstract

A novel magnetic MCM-41 nanocomposite-based catalyst is reported for the first time in the multicomponent synthesis of trisubstituted pyrimidines in which piperazine is immobilized inside the mesochannels of magnetic MCM-41 as an organic base (α-Fe2O3-MCM-41-piperazine). This nanocatalyst was thoroughly characterized by various techniques such as FT-IR, XRD, SEM, TEM, EDX and N2-adsorption isotherms. Very uniform dispersion and ordered mesopores of α-Fe2O3-MCM-41 causes piperazine molecules to be distributed very finely on the internal surface of the pores, resulting in a very useful and robust magnetically recyclable amine-based heterogeneous nanocatalyst. This catalytic system showed remarkable activity in the solvent-free synthesis of 2,4,6-trisubstituted pyrimidine derivatives.

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Acknowledgments

The authors gratefully acknowledge Prof. Rostamizadeh from K. N. Toosi University of Technology, and Dr. Jadidi from Shahid Beheshti University G. C. for their helpful consultations. The partial financial support of the present study by the Research Council of the University of Zabol is also gratefully acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, University of Zabol, Zabol, P. O. Box: 9861335856, Iran

    Reza Aryan, Hamid Beyzaei, Masoomeh Nojavan & Tahereh Dianatipour

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  1. Reza Aryan
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  2. Hamid Beyzaei
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  3. Masoomeh Nojavan
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  4. Tahereh Dianatipour
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Correspondence to Reza Aryan.

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Aryan, R., Beyzaei, H., Nojavan, M. et al. Secondary amines immobilized inside magnetic mesoporous materials as a recyclable basic and oxidative heterogeneous nanocatalyst for the synthesis of trisubstituted pyrimidine derivatives. Res Chem Intermed 42, 4417–4431 (2016). https://doi.org/10.1007/s11164-015-2284-y

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