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Synthesis, characterization and cytotoxic activity of ferrocenyl hydrazone complexes containing a furan moiety

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Abstract

A ferrocenyl ligand 1 was prepared from condensation of 5-methyl-2-furaldehyde with l,l′-diacetylferrocene dihydrazone. This ligand forms 1:1 complexes with cobalt(II), nickel(II), copper(II) and zinc(II) 2–5 in good yield. Characterization of the ligand and complexes was carried out using infrared, nuclear magnetic resonance, mass spectra, electronic absorption, magnetic susceptibility, molar conductivity, and elemental analysis. Cytotoxic activity of the prepared ligand and its complexes were tested against different human cancer cell lines. The results suggested that the synthesized compounds were more potent than the comparative standards drugs used in most cases, whereas they had less activity in the others.

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Acknowledgments

Mokhles M. Abd-Elzaher would like to thank DAAD for a research fellowship, and thank Prof. N. Burzlaff for providing laboratory facilities at University of Erlangen-Nuremberg (Germany).

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Authors and Affiliations

  1. Inorganic Chemistry Department, National Research Centre, 33 El Beehouth St., PO 12622, Dokki, Cairo, Egypt

    Mokhles M. Abd-Elzaher, Ammar A. Labib, Hanan A. Mousa & Samia A. Moustafa

  2. Research Unit, Saco Pharm. Co., 6th October City, 11632, Egypt

    Mohamed M. Abdallah

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  1. Mokhles M. Abd-Elzaher
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  2. Ammar A. Labib
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Correspondence to Mokhles M. Abd-Elzaher.

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Abd-Elzaher, M.M., Labib, A.A., Mousa, H.A. et al. Synthesis, characterization and cytotoxic activity of ferrocenyl hydrazone complexes containing a furan moiety. Res Chem Intermed 40, 1923–1936 (2014). https://doi.org/10.1007/s11164-013-1090-7

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