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Syntheses, crystal structures, antitumor and antioxidant activities of two hydrazide–hydrazone-based transition metal complexes

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Abstract

Two isostructural hydrazide–hydrazone-based complexes, namely [Zn(L)(HL)(ClO4)]·H2O and [Ni(L)(HL)(ClO4)]·H2O (HL = 2-acetylpyridine isonicotinohydrazone), have been obtained and characterized by physicochemical and spectroscopic methods. In each complex, the first ligand is in the neutral keto form, while the second is in the deprotonated monoanionic enolate form. Both complexes have excellent antitumor activity toward A549 human lung cancer, and BGC823 and SGC7901 human gastric cancer cell lines. Furthermore, both complexes are active scavengers for O −·2 and OH·, exerting superior activities compared to the free ligand.

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Acknowledgments

This work was supported in part by the National Natural Science Foundation of China (Nos. 21404033, 21401046), the Education Department of Henan Province (Nos. 12B150011 and 14B150029), the Foundation of Science and Technology of Yixing (2013-21), the Foundation of the Natural Science Foundation of Jiangsu (BK20141122), the Doctoral Scientific Fund Project of Henan Polytechnic University (72515/086, 61307/003), and the Foundation of State Key Laboratory of Solid Lubrication (LSL-1207).

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Authors and Affiliations

  1. Department of Physics and Chemistry, Henan Polytechnic University, Jiaozuo, 454000, Henan Province, China

    Hui-Qin Chang, Lei Jia, Jun Xu, Wei-Na Wu, Yuan Wang & Zhou-Qing Xu

  2. Department of Respiratory, The Affiliated Yixing Hospital of Jiangsu University, Yixing, 214200, Jiangsu Province, China

    Tao-Feng Zhu & Ru-Hua Chen

  3. Central Laboratory, The Affiliated Yixing Hospital of Jiangsu University, Yixing, 214200, Jiangsu Province, China

    Tie-Liang Ma

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  1. Hui-Qin Chang
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  2. Lei Jia
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  5. Tao-Feng Zhu
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  8. Yuan Wang
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Corresponding authors

Correspondence to Lei Jia or Yuan Wang.

Appendix A: Supplementary data

Appendix A: Supplementary data

Crystallographic data for complexes 1 and 2 have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication CCDC reference numbers are 1043687 and 1043688, respectively. Copies of the data can be obtained, free of charge, on application to the CCDC, 12 Union Road, Cambridge CB2 1EZ, UK. Tel: +44-01223-762910; fax: +44-01223-336033; e-mail: deposit@ccdc.cam.ac.uk or http://www.ccdc.cam.ac.uk.

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Chang, HQ., Jia, L., Xu, J. et al. Syntheses, crystal structures, antitumor and antioxidant activities of two hydrazide–hydrazone-based transition metal complexes. Transition Met Chem 40, 485–491 (2015). https://doi.org/10.1007/s11243-015-9938-x

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  • DOI: https://doi.org/10.1007/s11243-015-9938-x

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