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Phenolic Compounds of Endemic Buxus Plants in Caspian Hyrcanian Forest (Buxus Hyrcana Pojark) and Their Biological Activities

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Pharmaceutical Chemistry Journal Aims and scope

The present paper describes the bioactive constituents and the antioxidant, antibacterial, and antiproliferative properties of extracts from fruits, stems and leaves of Buxus hyrcana Pojark, flowering plant species of the genus Buxus. The obtained data of HPLC and GC-MS analyses show that gallic acid, resorcinol, epicatechin, and ferulic acid are the major phenolic constituents, and quercetin and genistein are the major flavonoid and isoflavonoid compounds present in all parts of B. hyrcana. In addition, GC-MS measurements showed that main constituents in B. hyrcana extracts were glycerin 1,2,3-propanetriol (52%), 2,3-butanediol (49.56%), and 2-hexyl-1-octanol (9.64%). The leaf extract exhibited maximum antioxidant activity as compared to the stem and fruit extracts. The leaf extract also showed higher activity against Gram-negative bacteria, while the stem extract exhibited higher activity against Gram-positive species. In addition, all extracts demonstrated moderate to strong cytotoxic activity against human hepatocytes (Chang liver cells) and breast cancer cell line. This is the first report on bioactive compound profiles and their biological potential in extracts of various aerials part of B. hyrcana. Present studies will open ways to a large spectrum of natural bioactive compounds and their use in pharmaceutical and food industries as antioxidant, antibacterial, and nutraceutical constituents.

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References

  1. L. A. Pham-Huy, H. He, and C. Pham-Huy, Int. J. Biomed. Sci.,4, 89 (2008).

    CAS  PubMed  PubMed Central  Google Scholar 

  2. J. K. Willcox, S. L. Ash, and G. L. Catignani, Crit. Rev. Food Sci. Nutr.,44, 275 – 295 (2004).

    Article  CAS  Google Scholar 

  3. Y. S. Velioglu, G. Mazza, L. Gao, et al., J. Agric. Food Chem.,46, 4113 – 4117 (1998).

    Article  CAS  Google Scholar 

  4. J. A. Vinson, Y. Hao, X. Su, et al., J. Agric. Food Chem.,46, 3630 – 3634 (1998).

    Article  CAS  Google Scholar 

  5. M. I. Choudhary, S. Shahnaz, S. Parveen, et al., J. Nat. Prod.,66, 739 – 742 (2003).

    Article  CAS  Google Scholar 

  6. J. Durant, P. Chantre, G. Gonzalez, et al., Phytomedicine,5, 1 – 10 (1998).

    Article  CAS  Google Scholar 

  7. L. B. Pagliosa, S. C. Monteiro, K. B. Silva, et al., Phytomedicine,17, 698 – 701 (2010).

    Article  CAS  Google Scholar 

  8. D. K. Kim, K. T. Lee, N. I. Baek, et al., Arch. Pharm. Res.,27, 1127 – 1131 (2004).

    Article  CAS  Google Scholar 

  9. E. L. Konrath, M. G. Ortega, S. de Loreto Bordignon, et al., J. Enzyme Inhib. Med. Chem.,28, 218 – 222 (2013).

    Article  CAS  Google Scholar 

  10. M. T. Andrade, J. A. Lima, A. C. Pinto, et al., Bioorg. Med. Chem.,13, 4092 – 4095 (2005).

    Article  CAS  Google Scholar 

  11. M. A. Mesaik, S. A. Halim, Z. Ul?Haq, et al., Chem. Biol. Drug. Des.,75, 310 – 317 (2010).

  12. Z. U. Babar, A. Ata, and M. H. Meshkatalsadat, Steroids,71, 1045 – 1051 (2006).

    Article  CAS  Google Scholar 

  13. H. I. Ismail, K.W. Chan, A. A. Mariod, et al., Food Chem.,119, 643 – 647 (2010).

    Article  CAS  Google Scholar 

  14. V. Jaitak, K. Sharma, K. Kalia, et al., J. Food Compos. Anal.,23, 142 – 147 (2010).

    Article  CAS  Google Scholar 

  15. E. Karimi, and H. Jaafar, Molecules,16, 6791 – 6805 (2011).

    Article  CAS  Google Scholar 

  16. G. C. Yen, and P. D. Duh, J. Agric. Food Chem.,42, 629 – 632 (1994).

    Article  CAS  Google Scholar 

  17. G. C. Yen, and H. Y. Chen, J. Agric. Food Chem.,43, 27 – 32 (1995).

    Article  CAS  Google Scholar 

  18. M. S. Giao, M. L. González-Sanjosé, M. D. Rivero-Pérez, et al., J. Sci. Food Agric.,87, 2638 – 2647 (2007).

    Article  CAS  Google Scholar 

  19. O. Boussaada, J. Chriaa, R. Nabli, et al., World J. Microbiol. Biotechnol.,24, 1289 – 1296 (2008).

    Article  Google Scholar 

  20. E. Karimi, H. Z. E. Jaafar, and A. Ghasemzadeh, NJAS Wageningen J. Life Sci.,78, 85 – 91 (2016).

    Article  Google Scholar 

  21. G. R. Velderrain-Rodríguez, H. Palafox-Carlos, A.Wall-Medrano, et al., Food Funct.,5, 189 – 197 (2014).

    Article  Google Scholar 

  22. M. A. Ebrahimzadeh, S. F. Nabavi, S. M. Nabavi, et al., Afr. J. Biotechnol.,9, 5212 – 5217 (2010).

    CAS  Google Scholar 

  23. S. H. Häkkinen, S. O. Kärenlampi, M. Heinonen, et al., J. Agric. Food Chem.,47, 2274 – 2279 (1999).

    Article  Google Scholar 

  24. A. Crozier, M. E. J. Lean, M. S. McDonald, et al., J. Agric. Food Chem.,45, 590 – 595 (1997).

    Article  CAS  Google Scholar 

  25. H. Ha, Y. S. Lee, J. H. Lee, et al., Arch. Pharm. Res.,29, 96 – 101 (2006).

    Article  CAS  Google Scholar 

  26. F. Bakkali, S. Averbeck, D. Averbeck, et al., Food Chem. Toxicol.,46, 446 – 475 (2008).

    Article  CAS  Google Scholar 

  27. A. Vafaei, J. Bin Mohamad, and E. Karimi, Nat. Prod. Res., 33, 2531 – 2535 (2018).

    Article  Google Scholar 

  28. E. Karimi, P. Mehrabanjoubani, M. Homayouni-Tabrizi, et al., J. Food Measur. Charact.,12, 433–440 (2018).

    Article  Google Scholar 

  29. E. Souri, G. Amin, A. Dehmobed-Sharifabadi, et al., Iran J. Pharm. Res., 55 – 59 (2010).

  30. J. R. Villagómez-Ibarra, M. Sánchez, O. Espejo, et al., Fitoterapia,72, 692 – 694 (2001).

    Article  Google Scholar 

  31. G. Loy, F. Cottiglia, D. Garau, et al., IL Farmaco,56, 433 – 436 (2001).

    Article  CAS  Google Scholar 

  32. P. Anand, A. B. Kunnumakkara, C. Sundaram, et al., Pharm. Res.,25, 2097 – 2116 (2008).

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors would like to thank the Islamic Azad University of Mashhad for sponsoring this investigation

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Authors and Affiliations

  1. Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran

    Ehsan Karimi, Ali Es-Haghi & Jamshidkhan Chamani

  2. Department of Basic Science, Faculty of Animal Science and Fisheries, Sari Agricultural Sciences and Natural Resources University, Sari, Iran

    Pooyan Mehrabanjoubani

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  1. Ehsan Karimi
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  2. Pooyan Mehrabanjoubani
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  3. Ali Es-Haghi
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  4. Jamshidkhan Chamani
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Correspondence to Ehsan Karimi.

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Karimi, E., Mehrabanjoubani, P., Es-Haghi, A. et al. Phenolic Compounds of Endemic Buxus Plants in Caspian Hyrcanian Forest (Buxus Hyrcana Pojark) and Their Biological Activities. Pharm Chem J 53, 741–747 (2019). https://doi.org/10.1007/s11094-019-02072-2

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  • DOI: https://doi.org/10.1007/s11094-019-02072-2

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