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A Review on Potential Footprints of Ferulic Acid for Treatment of Neurological Disorders

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Abstract

Ferulic acid is being screened in preclinical settings to combat various neurological disorders. It is a naturally occurring dietary flavonoid commonly found in grains, fruits, and vegetables such as rice, wheat, oats, tomatoes, sweet corn etc., which exhibits protective effects against a number of neurological diseases such as epilepsy, depression, ischemia-reperfusion injury, Alzheimer’s disease, and Parkinson’s disease. Ferulic acid prevents and treats different neurological diseases pertaining to its potent anti-oxidative and anti-inflammatory effects, beside modulating unique neuro-signaling pathways. It stays in the bloodstream for longer periods than other dietary polyphenols and antioxidants and easily crosses blood brain barrier. The use of novel drug delivery systems such as solid-lipid nanoparticles (SLNs) or its salt forms (sodium ferulate, ethyl ferulate, and isopentyl ferulate) further enhance its bioavailability and cerebral penetration. Based on reported studies, ferulic acid appears to be a promising molecule for treatment of neurological disorders; however, more preclinical (in vitro and in vivo) mechanism-based studies should be planned and conceived followed by its testing in clinical settings.

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Authors and Affiliations

  1. Department of Pharmacology, All India Institute of Medical Sciences, Rishikesh, 249203, India

    Surabhi Thapliyal, Shailendra Handu, Manisha Bisht, Pallavi Srivastava & Ravi Gandham

  2. Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KT, 40508, USA

    Tanveer Singh

  3. Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India

    Puja Kumari

  4. Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard (Hamdard University), 110062, New Delhi, India

    Priyanka Arya

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  1. Surabhi Thapliyal
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Thapliyal, S., Singh, T., Handu, S. et al. A Review on Potential Footprints of Ferulic Acid for Treatment of Neurological Disorders. Neurochem Res 46, 1043–1057 (2021). https://doi.org/10.1007/s11064-021-03257-6

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