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The Neuroprotective Role of Fisetin in Different Neurological Diseases: a Systematic Review

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Abstract

Neurological diseases place a substantial burden on public health and have a serious impact on the quality of life of patients. Despite the multifaceted pathological process involved in the occurrence and development of these neurological diseases, each disease has its own unique pathological characteristics and underlying molecular mechanisms which trigger their onset. Thus, it is unlikely to achieve effective treatment of neurological diseases by means of a single approach. To this end, we reason that it is pivotal to seek an efficient strategy that implements multitherapeutic targeting and addresses the multifaceted pathological process to overcome the complex issues related to neural dysfunction. In recent years, natural medicinal plant–derived monomers have received extensive attention as new neuroprotective agents for treatment of neurological disorders. Fisetin, a flavonoid, has emerged as a novel potential molecule that enhances neural protection and reverses cognitive abnormalities. The neuroprotective effects of fisetin are attributed to its multifaceted biological activity and multiple therapeutic mechanisms associated with different neurological disorders. In this review article, we summarize recent research progression regarding the pharmacological effects of fisetin in treating several neurological diseases and the potential mechanisms.

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Acknowledgements

The authors would like to Dr. Huiming Xu for the critical reading of the manuscript.

Funding

This work was supported by the National Natural Science Foundation of China (grant nos. 82071551 and 81830077), and the key research and development program in Ningxia Hui Autonomous Region (grant nos. 2022BEG02032)

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  1. Yizhen Jiang and Xiangwen Tang contributed equally to this work.

Authors and Affiliations

  1. Translational Medicine Center, Hong Hui Hospital, Xi’an Jiaotong University, Xi’an, 710054, China

    Yizhen Jiang, Chao Jiang & Hao Yang

  2. Basic Medical school Academy, Shaanxi University of Traditional Chinese Medicine, Xianyang, 712046, China

    Yizhen Jiang, Xiangwen Tang & Peng Deng

  3. School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, 750004, Ningxia, China

    Yuqing He

  4. Department of Spine Surgery, Hong Hui Hospital, Xi’an Jiaotong University, Xi’an, 710054, China

    Dingjun Hao

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HY conceived the review and supervised the project. YZJ and XWT wrote the manuscript. PD and CJ contributed to the literature review and editing. YQH contributed to the literature review and drew the figure. YH and DJH contributed to the content and editing. All authors read and approved the final version of the manuscript.

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Correspondence to Hao Yang.

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Jiang, Y., Tang, X., Deng, P. et al. The Neuroprotective Role of Fisetin in Different Neurological Diseases: a Systematic Review. Mol Neurobiol 60, 6383–6394 (2023). https://doi.org/10.1007/s12035-023-03469-7

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