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Long Non-coding RNAs in Parkinson’s Disease

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Abstract

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder and is associated with a range of motor and non-motor clinical symptoms. The underlying molecular pathogenesis of PD involves a variety of pathways and mechanisms, including α-synuclein proteostasis, mitochondrial dysfunction, oxidative stress, autophagy and apoptosis, neuroinflammation, and epigenetic regulation. Long non-coding RNAs (lncRNAs) are involved in the regulation of multiple pathological processes of PD. In this review, we provide an overview of large-scale studies on lncRNA expression profiling in PD patients and models, as well as highlight the impacts of lncRNAs on the pathogenesis of PD, which could provide basic information regarding the putative lncRNA-based biomarkers and therapeutic targets for the early diagnosis and treatment strategies for PD.

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Funding

This work was supported by grants from the Liaoning Province Natural Science Foundation (20180550833) to CQX, and National stem cell clinical research registered project (CMR-20161129-1003) to JL.

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  1. Stem Cell Clinical Research Center, National Joint Engineering Laboratory, Regenerative Medicine Center, The First Affiliated Hospital of Dalian Medical University, No. 193, Lianhe Road, Shahekou District, Dalian City, Liaoning Province, 116011, People’s Republic of China

    Chengqi Xin & Jing Liu

  2. Dalian Innovation Institute of Stem Cell and Precision Medicine, No. 57, Xinda Street, Dalian High-Tech Park, Dalian City, Liaoning Province, 116023, People’s Republic of China

    Chengqi Xin & Jing Liu

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  1. Chengqi Xin
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JL had the idea for the article, CQX performed the literature search, CQX and JL drafted and critically revised the work. Both authors have read and approved the final version of the manuscript.

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Correspondence to Jing Liu.

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Xin, C., Liu, J. Long Non-coding RNAs in Parkinson’s Disease. Neurochem Res 46, 1031–1042 (2021). https://doi.org/10.1007/s11064-021-03230-3

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