Skip to main content
SpringerLink
Log in

Significant heterogeneity in the geographical distribution of diffuse grade II/III gliomas in France

  • Clinical Study
  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

Diffuse WHO grade II and III gliomas (DGII/IIIG) are rare tumors, with few specific epidemiological studies. We aimed at describing the geographical distribution of a homogeneous series of histologically confirmed DGII/IIIG, over a four-year period (2006–2009), at a national level. The methodology is based on a multidisciplinary national network already established by the French Brain Tumor DataBase and data collected directly from every neuropathology department. Personal home addresses were collected for confirmed cases. For each region, the incidence of DGII/IIIG was analyzed and standardized on the age and sex distribution of the French population. The number of patients with newly diagnosed, histologically confirmed DGII/IIIG was 4,790. The overall crude rate was 19.4/106. To enable international comparisons, standardized rates were calculated as follows: 19.8/106, 18.8/106 and 16.0/106 (reference population, Europe, US and world, respectively). The geographical distribution by region showed significant differences, with higher incidence rates in Northeast and central parts of France. This work is the first studying the geographical distribution of a pure series of DGII/IIIG at a national level. It demonstrates significant heterogeneity in the distribution, and raises the question of the role of environmental and/or genetic risk(s) factor(s) for DGII/IIIG.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Louis DN, Ohgaki H, Wiestler OD et al (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114:97–109

    Article  PubMed Central  PubMed  Google Scholar 

  2. Dolecek TA, Propp JM, Stroup NE, Kruchko C (2012) CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005-2009. Neuro Oncol 14(suppl 5):v1–v49

    Article  PubMed Central  PubMed  Google Scholar 

  3. Ohgaki H, Kleihues P (2005) Epidemiology and etiology of gliomas. Acta Neuropathol 109:93–108

    Article  PubMed  Google Scholar 

  4. Wöhrer A, Waldhör T, Heinzl H et al (2009) The Austrian Brain Tumour Registry: a cooperative way to establish a population-based brain tumour registry. J Neurooncol 95:401–411

    Article  PubMed  Google Scholar 

  5. Baldi I, Gruber A, Alioum A et al (2011) Descriptive epidemiology of CNS tumors in France: results from the Gironde Registry for the period 2000-2007. Neuro Oncol 13:1370–1378

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  6. Ron E, Modan B, Boice JD, Alfandary E, Stovall M, Katz L (1988) Tumors of the brain and nervous system after radiotherapy in childhood. N Engl J Med 319:1033–1039

    Article  CAS  PubMed  Google Scholar 

  7. Yonehara S, Brenner AV, Kishikawa M et al (2004) Clinical and epidemiologic characteristics of first primary tumors of the central nervous system and related organs among atomic bomb survivors in Hiroshima and Nagasaki, 1958-1995. Cancer 101:1644–1654

    Article  PubMed  Google Scholar 

  8. Bondy ML, Scheurer ME, Malmer B et al (2008) Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium. Cancer 113(7 Suppl):1953–1968

    Article  PubMed Central  PubMed  Google Scholar 

  9. McCarthy BJ, Rankin KM, Aldape K et al (2011) Risk factors for oligodendroglial tumors: a pooled international study. Neuro Oncol 13:242–250

    Article  PubMed Central  PubMed  Google Scholar 

  10. Crocetti E, Trama A, Stiller C et al (2012) Epidemiology of glial and non-glial brain tumours in Europe. Eur J Cancer 48:1532–1542

    Article  PubMed  Google Scholar 

  11. Houben MP, Coebergh JW, Birch JM, Tijssen CC, van Duijn CM, McNally RJ (2005) Space–time clustering patterns of gliomas in the Netherlands suggest an infectious aetiology. Eur J Cancer 41:2917–2923

    Article  CAS  PubMed  Google Scholar 

  12. Houben MP, Coebergh JW, Birch JM, Tijssen CC, van Duijn CM, McNally RJ (2006) Space-time clustering of glioma cannot be attributed to specific histological subgroups. Eur J Epidemiol 21:197–201

    Article  CAS  PubMed  Google Scholar 

  13. Bauchet L, Rigau V, Mathieu-Daudé H et al (2007) French brain tumor data bank: methodology and first results on 10,000 cases. J Neurooncol 84:189–199

    Article  PubMed  Google Scholar 

  14. Bauchet L, Rigau V, Mathieu-Daudé H et al (2009) Clinical epidemiology for childhood primary central nervous system tumors. J Neurooncol 92:87–98

    Article  PubMed  Google Scholar 

  15. Bauchet L, Mathieu-Daudé H, Fabbro-Peray P et al (2010) Oncological patterns of care and outcome for 952 patients with newly diagnosed glioblastoma in 2004. Neuro Oncol 12:725–735

    Article  PubMed Central  PubMed  Google Scholar 

  16. Rigau V, Zouaoui S, Mathieu-Daudé H et al (2012) French brain tumor database: 5- year histological results on 25756 cases. Brain Pathol 21:633–644

    Article  Google Scholar 

  17. Zouaoui S, Rigau V, Mathieu-Daudé H et al (2012) French brain tumor database: general results on 40,000 cases, main current applications and future prospects. Neurochirurgie 58:4–13

    Article  CAS  PubMed  Google Scholar 

  18. Hartmann C, von Deimling A (2009) Molecular pathology of oligodendroglial tumors. Recent Results Cancer Res 171:25–49

    Article  PubMed  Google Scholar 

  19. van den Bent MJ (2010) Interobserver variation of the histopathological diagnosis in clinical trials on glioma: a clinician’s perspective. Acta Neuropathol 120(3):297–304

    Article  PubMed Central  PubMed  Google Scholar 

  20. Davis FG, Malmer BS, Aldape K et al (2008) Issues of diagnostic review in brain tumor studies: from the Brain Tumor Epidemiology Consortium. Cancer Epidemiol Biomarkers Prev 17(3):484–489

    Article  PubMed  Google Scholar 

  21. Okamoto Y, Di Patre P-L, Burkhard C, Horstmann S, Jourde B, Fahey M et al (2004) Population-based study on incidence, survival rates, and genetic alterations of low-grade diffuse astrocytomas and oligodendrogliomas. Acta Neuropathol 108:49–56

    Article  PubMed  Google Scholar 

  22. Arora RS, Alston RD, Eden TO et al (2010) Are reported increases in incidence of primary CNS tumours real ? An analysis of longitudinal trends in England, 1979-2003. Eur J Cancer 46:1607–1616

    Article  PubMed  Google Scholar 

  23. Chan DS, Lau R, Aune D et al (2011) Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies. PLoS One 6(6):e20456

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  24. Aleksandrova K, Nimptsch K, Pischon T (2013) Influence of obesity and related metabolic alterations on colorectal cancer risk. Curr Nutr Rep 2(1):1–9

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  25. Boeing H, Schlehofer B, Blettner M, Wahrendorf J (1993) Dietary carcinogens and the risk for glioma and meningioma in Germany. Int J Cancer 53(4):561–565

    Article  CAS  PubMed  Google Scholar 

  26. Blowers L, Preston-Martin S, Mack WJ (1997) Dietary and other lifestyle factors of women with brain gliomas in Los Angeles County (California, USA). Cancer Causes Control 8:5–12

    Article  CAS  PubMed  Google Scholar 

  27. Kyritsis AP, Bondy ML, Levin VA (2011) Modulation of glioma risk and progression by dietary nutrients and antiinflammatory agents. Nutr Cancer 63(2):174–184

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  28. Huncharek M, Kupelnick B, Wheeler L (2003) Dietary cured meat and the risk of adult glioma: a meta-analysis of nine observational studies. J Environ Pathol Toxicol Oncol 22(2):129–137

    CAS  PubMed  Google Scholar 

  29. Michaud DS, Holick CN, Batchelor TT, Giovannucci E, Hunter DJ (2009) Prospective study of meat intake and dietary nitrates, nitrites, and nitrosamines and risk of adult glioma. Am J Clin Nutr 90:570–577

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  30. Dubrow R, Daresky AS, Park Y et al (2010) Dietary components related to N-Nitroso compound formation: a prospective study of adult glioma. Cancer Epidemiol Biomarkers Prev 19(7):1709–1722

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  31. Fromont A, Binquet C, Sauleau EA et al (2010) Geographic variations of multiple sclerosis in France. Brain 133:1889–1899

    Article  PubMed  Google Scholar 

  32. Fromont A, Binquet C, Sauleau E et al (2012) National estimate of multiple sclerosis incidence in France (2001-2007). Mult Scler 18(8):1108–1115

    Article  CAS  PubMed  Google Scholar 

  33. Vukusic S, Van Bockstael V, Gosselin S, Confavreux C (2006) Regional variations in the prevalence of multiple sclerosis in French farmers. J Neurol Neurosurg Psychiatry 78:707–709

    Article  Google Scholar 

  34. Ebers GC (2008) Environmental factors and multiple sclerosis. Lancet Neurol 7(3):268–277

    Article  PubMed  Google Scholar 

  35. Kampman MT, Wilsgaard T, Mellgren SI (2007) Outdoor activities and diet in childhood and adolescence relate to MS risk above the Arctic Circle. J Neurol 254(4):471–477

    Article  CAS  PubMed  Google Scholar 

  36. Mohr SB, Gorham ED, Garland CF, Grant WB, Garland FC (2010) Low ultraviolet B and increased risk of brain cancer: an ecological study of 175 countries. Neuroepidemiology 35(4):281–290

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

The authors wish to thank all pathologists, neurosurgeons and other stakeholders, for their help and input with this work (see the list in supplementary materials), and Bénédicte Clément, scientific translator, for valuable translation work. This work was conducted with the financial support in the form of grants from the Ligue Nationale Contre le Cancer, Association des Neuro-Oncologues d’Expression Française, Société Française de Neurochirurgie, Associations pour la Recherche sur les Tumeurs Cérébrales (ARTC and ARTC Sud), Roche Laboratory, Sophysa Laboratory, Département de l’Hérault, and Groupe de Neuro-Oncologie du Languedoc Roussillon.

Conflict of interest

None declared.

Author information

Authors and Affiliations

  1. Departement of Medical Oncology and Department of Radiation Oncology, Institut Régional du Cancer de Montpellier - Val d’Aurelle, Montpellier, France

    Amélie Darlix, Michel Fabbro & Christine Kerr

  2. INSERM U1051, Montpellier, France

    Amélie Darlix, Sonia Zouaoui, Hugues Duffau & Luc Bauchet

  3. Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier, France

    Sonia Zouaoui, Hugues Duffau & Luc Bauchet

  4. Department of Epidemiology, French Brain Tumor Database, GNOLR, Registre des Tumeurs de l’Hérault, Institut Régional du Cancer de Montpellier - Val d’Aurelle, Montpellier, France

    Sonia Zouaoui, Hélène Mathieu-Daudé, Faiza Bessaoud, Brigitte Trétarre & Fabienne Bauchet

  5. Department of Clinical Epidemiology and Evaluation, University Hospital, Nancy, France

    Jean-Marc Virion

  6. Department of Pathology, Gui de Chauliac Hospital, Montpellier, France

    Valérie Rigau

  7. Neuro-oncology Unit, Central Hospital, Nancy, France

    Marie Blonski

  8. Department of Neurology, Pitié-Salpétrière Hospital, Paris, France

    German Reyes-Botero

  9. Department of Neurosurgery, Pitié-Salpétrière Hospital, Paris, France

    Laurent Capelle

  10. Department of Neuropathology and INSERM U911, Timone Hospital, Université de la Méditerranée, Marseille, France

    Dominique Figarella-Branger

  11. Neuro-oncology Unit, University Hospital, Poitiers, France

    Luc Taillandier

Authors
  1. Amélie Darlix
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sonia Zouaoui
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jean-Marc Virion
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Valérie Rigau
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hélène Mathieu-Daudé
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Marie Blonski
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. German Reyes-Botero
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Faiza Bessaoud
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Brigitte Trétarre
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Fabienne Bauchet
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Laurent Capelle
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Michel Fabbro
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Christine Kerr
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Dominique Figarella-Branger
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Hugues Duffau
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Luc Taillandier
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. Luc Bauchet
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Amélie Darlix.

Additional information

Amélie Darlix and Sonia Zouaoui equally contributed to the study.

Electronic supplementary material

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Darlix, A., Zouaoui, S., Virion, JM. et al. Significant heterogeneity in the geographical distribution of diffuse grade II/III gliomas in France. J Neurooncol 120, 547–555 (2014). https://doi.org/10.1007/s11060-014-1585-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11060-014-1585-0

Keywords

Search

Navigation