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Subtelomeric analysis of pediatric astrocytoma: subchromosomal instability is a distinctive feature of pleomorphic xanthoastrocytoma

  • Laboratory Investigation - Human/animal tissue
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Abstract

Astrocytic neoplasms are genetically heterogeneous; however a low frequency of genomic changes has been found in juvenile pilocytic astrocytoma (PA) in molecular studies. Concerning pleomorphic xanthoastrocytomas (PXA), recent studies have given heterogeneous results for chromosomal alterations. We studied the subtelomeric regions of 19 primary astrocytoma tumors. Results were near normality for the PA group with relative scarcity of chromosomal imbalances, except for the duplication of 3pter in 4/15 and deletion of 21qter in 5/15 of them. In contrast, a specific profile was observed in the 4 PXA tumoral samples. This involved 3pter, 14qter and 19pter duplication and 4qter, 6qter, 9qter, 13cen, 17pter, 18qter and 21qter deletion. Our results indicate that the chromosomal and genetic aberrations in PXAs differed from those typically associated with the diffusely infiltrating astrocytic and oligodendroglial gliomas. These genetic differences would likely contribute to the more favorable behavior of PXAs and may be helpful for molecular differential diagnosis of pediatric cerebral tumors.

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Acknowledgements

This study was supported by grants AP091/06 (Conselleria de Sanitat). We would also thanks Miss Desiree Ramal for her valuable help on data manager labors. English text revised by F. Barraclough.

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Authors and Affiliations

  1. Unidad de Genética y Diagnóstico Prenatal, Hospital Universitario La Fe, Av/Campanar 21, 46009, Valencia, Spain

    Elena Grau, F. Martinez, C. Orellana & S. Oltra

  2. Unidad de Oncología Pediátrica, Hospital Universitario La Fe, Valencia, Spain

    Elena Grau, J. Balaguer, A. Canete & V. Castel

  3. Unidad de Anatomía Patológica, Hospital Universitario La Fe, Valencia, Spain

    M. Hernandez

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  1. Elena Grau
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Correspondence to Elena Grau.

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Grau, E., Balaguer, J., Canete, A. et al. Subtelomeric analysis of pediatric astrocytoma: subchromosomal instability is a distinctive feature of pleomorphic xanthoastrocytoma. J Neurooncol 93, 175–182 (2009). https://doi.org/10.1007/s11060-008-9763-6

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  • DOI: https://doi.org/10.1007/s11060-008-9763-6

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