A comparative analysis of the contents of CD4+, CD8+, and CD16/32+ cells in the peripheral blood and spleen of intact (non-immunized) ASC mice with a genetically determined depression-like state and mice of the parental CBA strain, without depressive behavior, is presented. ASC mice showed decreases in the relative number of CD16/32+ and CD4+ cells, accumulation of CD8+ cells, and a decrease in the index of immunoreactivity (CD4/CD8). Changes in the subpopulations of study cells in intact ASC mice were accompanied by reduced responses of animals to a T-dependent antigen – sheep erythrocytes (5·108). There were significant reductions in the relative and absolute numbers of IgM-antibody-forming cells (AFC) on post-immunization days 4 and 5 and IgG AFC on day 6 in the spleens of ASC mice, as compared with CBA mice. The possible mechanisms of reductions in immunoreactivity in the genetically determined depression-like state are discussed.
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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 98, No. 2, pp. 194–201, February, 2012.
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Idova, G.V., Al’perina, E.L., Gevorgyan, M.M. et al. T-Lymphocyte Subpopulation Composition and the Immune Response in Depression-Like Behavior in ASC Mice. Neurosci Behav Physi 43, 946–950 (2013). https://doi.org/10.1007/s11055-013-9833-x
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DOI: https://doi.org/10.1007/s11055-013-9833-x