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An Analysis of Adaptive Reactions in Healthy Subjects Who Have Persistent and Prolonged Contact with Tuberculosis Patients

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Abstract—

Lasting contact of medical personnel in tuberculosis departments with the pathogen of Mycobacterium tuberculosis causes changes in their immune system, which is aimed at adapting the body to a constant antigenic load. Changes in the blood of medical staff indicate the participation of certain cells in the formation of protective immunity. Therefore, the observed changes are likely to be specific and reflect the formation of the protection of a healthy person’s organism from the development of tuberculosis. The question of the relevancy of the use of medical personnel blood parameters as a control over the health status of chronic tuberculosis patients is discussed. The most pronounced changes were observed in populations of monocytes and CD4+ T cells, which are directly involved in the protection of the human body against tuberculosis. The number of CD4+ T cells capable of producing interferon-gamma (IFN-γ) in response to stimulation by M. tuberculosis antigens was analyzed in the blood of medical personnel. The number of these cells in the blood of the medical staff varied depending on the duration of their work in clinic. Low level of CD4+ (IFN-γ)+ activated T cells in the blood of employees after 5–7 years of work can be a prognostic factor for low resistance to tuberculosis.

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ACKNOWLEDGMENTS

The authors sincerely thank all the employees of the Moscow tuberculosis hospital No. 7, whose blood helped carry out this work.

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Authors and Affiliations

  1. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia

    I. S. Litvinov & D. A. Dolgich

Authors
  1. I. S. Litvinov
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  2. D. A. Dolgich
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Correspondence to I. S. Litvinov.

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Conflict of interests. The authors declare that they have no conflict of interest.

Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.

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Translated by I. Shipounova

Abbreviations: mAb, monoclonal antibodies; INF-γ, interferon-γ; CIS, cellular immunity status; CBC, complete blood count; PB, peripheral blood; MTC, memory T cell.

Corresponding author: e-mail: catlismar@gmail.com.

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Litvinov, I.S., Dolgich, D.A. An Analysis of Adaptive Reactions in Healthy Subjects Who Have Persistent and Prolonged Contact with Tuberculosis Patients. Russ J Bioorg Chem 45, 173–178 (2019). https://doi.org/10.1134/S1068162019020067

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  • DOI: https://doi.org/10.1134/S1068162019020067

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