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Mixture toxicity of metal oxide nanoparticles and silver ions on Daphnia magna

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Abstract

Because of the ubiquitous production and use of silver nanoparticles (AgNPs), silver ions (Ag+) released from AgNPs can not only singly pose significant toxicity to aquatic ecosystems but can also mix with other coexisting metal oxide nanoparticles (MONPs), such as ZnO NPs and TiO2 NPs to provoke combined toxicity. However, information regarding the combined impact of MONPs on aquatic organisms is limited. In this study, the impact of exposure to mixtures composed of Ag+ and two different MONPs (i.e., ZnO NPs and TiO2 NPs) on Daphnia magna was examined. The toxicity of the mixtures containing Ag+ concentrations exceeding 0.5–1.5 μg/L and two different MONPs (Ag+-two different MONP mixture) was higher than that of the intrinsic toxicity of each component, indicating a synergistic effect. However, the concentrations of the two different MONPs did not have a strong relationship with the occurrence of the synergistic or antagonistic effect between components in the mixtures. Moreover, the combined risk of the Ag+-two different MONP mixture estimated based on a whole-value risk for the mixture (VaR:192–198) was up to eight times higher than that estimated using a component-based value risk (VaR:736–1623) considering the predicted environmental concentration of Ag+ (20 μg/L). These results imply that the component-based approach could not determine the synergistic effect between the components in the Ag+-two different MONP mixtures. Additionally, when mixed with two different MONPs, Ag+ as a major toxicant induced synergistic effects among the components in the mixture. Therefore, to evaluate the interactive effects and for environmental risk assessment of mixtures, a whole-mixture approach is recommended rather than a component-based approach.

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Abbreviations

AgNPs:

silver nanoparticles

Ag+ :

silver ion

ECx :

effective concentration values

ECx mix :

total effective concentration estimated from binary mixtures

HQs:

hazard quotients

MONPs:

metal oxide nanoparticles

OECD:

Organization for Econocmic Co-operation and Development

PEC:

predicted environmental concentration

PNEC:

predicted no effect concentration

STU:

the sum of toxic unit

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Funding

This research was supported by the National Research Council of Science & Technology (NST) grant by the South Korean government (MSIP) (No. CAP-17-01-KIST Europe) and Project 11911.

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Author notes

  1. Chang-Beom Park and Jae-Woong Jung contributed equally to this work.

Authors and Affiliations

  1. Department of Environmental Toxicology and Chemistry, Korea Institute of Toxicology (KIT), Jinju, 52834, South Korea

    Chang-Beom Park, Jae-Woong Jung, Jin-Woo Park, Dong-Hyuk Yeom & June-Woo Park

  2. KIST Europe Forschungsgesellschaft mbH, 66123, Saarbrücken, Germany

    Chang-Beom Park, Minjeong Baek, Baeckkyoung Sung, Yohan Seol & Young Jun Kim

Authors
  1. Chang-Beom Park
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  2. Jae-Woong Jung
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All authors contributed equally to this study. The final version of the manuscript has been approved by all authors.

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Correspondence to Young Jun Kim.

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Park, CB., Jung, JW., Baek, M. et al. Mixture toxicity of metal oxide nanoparticles and silver ions on Daphnia magna. J Nanopart Res 21, 166 (2019). https://doi.org/10.1007/s11051-019-4606-2

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