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Predictive multibody dynamic simulation of human neuromusculoskeletal systems: a review

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Abstract

Over the past decade, there has been a rapid increase in applications of multibody system dynamics to the predictive simulation of human movement. Using predictive “what-if” human dynamic simulations that do not rely on experimental testing or prototypes, new medical interventions and devices can be developed more quickly, cheaply, and safely. In this paper, we provide a comprehensive review of research into the predictive multibody dynamic simulation of human movements, with applications in clinical practice, medical and assistive device design, sports, and industrial ergonomics. Multibody models of human neuromusculoskeletal systems are reviewed, including models of joints, contacts, and muscle forces or torques, followed by a review of simulation approaches that use optimal control methods and a cost function to predict human movements. Modelling and optimal control software are also reviewed, and directions for future research are suggested.

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Data Availability

A detailed description of each modeling element and of each of the components of the optimization formulations for the most relevant predictive simulations in the literature can be found in an Excel file in the Supplementary material.

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Funding

This work was conducted with support from the Grant RTI2018-097290-B-C33 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”.

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Authors and Affiliations

  1. Biomechanical Engineering Lab, Department of Mechanical Engineering and Research Centre for Biomedical Engineering, Universitat Politècnica de Catalunya, Barcelona, Spain

    Míriam Febrer-Nafría & Josep M. Font-Llagunes

  2. Health Technologies and Innovation, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain

    Míriam Febrer-Nafría & Josep M. Font-Llagunes

  3. Department of Systems Design Engineering, University of Waterloo, Waterloo, ON, Canada

    Ali Nasr, Mahdokht Ezati, Peter Brown & John McPhee

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J.M., J.F-L., M.E. and M.F-N. conceived and designed the review content. All authors read and selected the references included in the review. M.F-N., A.N., M.E. and P.B. wrote the first version of Sections 2 and 3. J.M. and J.F-L. revised the manuscript and wrote the first version of Introduction and Conclusions. All authors reviewed the manuscript.

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Febrer-Nafría, M., Nasr, A., Ezati, M. et al. Predictive multibody dynamic simulation of human neuromusculoskeletal systems: a review. Multibody Syst Dyn 58, 299–339 (2023). https://doi.org/10.1007/s11044-022-09852-x

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