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Association between p53 codon 72 genetic polymorphisms and tobacco use and lung cancer risk in a Chinese population

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Abstract

Genetic polymorphisms of p53 codon 72 are thought to have significant effects on the metabolism of environmental carcinogens and thus on lung cancer risk, but the reported results are not always consistent. The aim of this study is to investigate the relationship between p53 codon 72 genetic polymorphisms and tobacco use and lung cancer risk in a Chinese population. A population-based control study was conducted in 360 lung cancer patients and 360 cancer-free controls. The genotype of the p53 codon 72 was determined by using a polymerase chain reaction–restriction fragment length polymorphism assay. Patients with lung cancer had a significantly lower frequency of Pro/Pro genotype [odds ratio (OR) = 0.58, 95 % confidence interval (CI) = 0.40, 0.84; P = 0.004] and Pro allele (OR = 0.72, 95 % CI = 0.59, 0.89; P = 0.002) than controls. Patients with squamous cell carcinoma had also a significantly lower frequency of Pro/Pro genotype (OR = 0.45, 95 % CI = 0.25, 0.82; P = 0.009). In the analysis combining p53 codon 72 polymorphisms and smoking, smokers who had smoked for more than 30 pack-years had a significantly lower frequency of Pro/Pro genotype (OR = 0.52, 95 % CI = 0.30, 0.92; P = 0.03) compared with non-smokers. This study suggests that p53 codon 72 polymorphisms play a role in the development of lung cancer and modifies the risk for smoking-related lung cancer in a Chinese population.

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References

  1. Jemal A, Bray F, Center MM et al (2011) Global cancer statistics. CA Cancer J Clin 61:69–90

    Article  PubMed  Google Scholar 

  2. Zhu J, Sharma DB, Gray SW et al (2012) Carboplatin and paclitaxel with vs without bevacizumab in older patients with advanced non-small cell lung cancer. JAMA 307:1593–1601

    Article  PubMed  CAS  Google Scholar 

  3. van Meerbeeck JP, Fennell DA, De Ruysscher DK (2011) Small-cell lung cancer. Lancet 378:1741–1755

    Article  PubMed  Google Scholar 

  4. Proctor RN (2001) Tobacco and the global lung cancer epidemic. Nat Rev Cancer 1:82–86

    Article  PubMed  CAS  Google Scholar 

  5. Ezzati M, Lopez AD (2003) Estimates of global mortality attributable to smoking in 2000. Lancet 362:847–852

    Article  PubMed  Google Scholar 

  6. Khuder SA (2001) Effect of cigarette smoking on major histological types of lung cancer: a meta-analysis. Lung Cancer 31:139–148

    Article  PubMed  CAS  Google Scholar 

  7. Hollstein M, Sidransky D, Vogelstein B et al (1991) p53 mutations in human cancers. Science 253:49–53

    Article  PubMed  CAS  Google Scholar 

  8. Matlashewski GJ, Tuck S, Pim D et al (1987) Primary structure polymorphism at amino acid residue 72 of human p53. Mol Cell Biol 7:961–963

    PubMed  CAS  Google Scholar 

  9. Klug SJ, Ressing M, Koenig J et al (2009) TP53 codon 72 polymorphism and cervical cancer: a pooled analysis of individual data from 49 studies. Lancet Oncol 10:772–784

    Article  PubMed  CAS  Google Scholar 

  10. Dai S, Mao C, Jiang L et al (2009) P53 polymorphism and lung cancer susceptibility: a pooled analysis of 32 case-control studies. Hum Genet 125:633–638

    Article  PubMed  CAS  Google Scholar 

  11. Weston A, Godbold JH (1997) Polymorphisms of H-ras-1 and p53 in breast cancer and lung cancer: a meta-analysis. Environ Health Perspect 105(Suppl 4):919–926

    Article  PubMed  CAS  Google Scholar 

  12. Caceres DD, Quinones LA, Schroeder JC et al (2009) Association between p53 codon 72 genetic polymorphism and tobacco use and lung cancer risk. Lung 187:110–115

    Article  PubMed  CAS  Google Scholar 

  13. Ekim M, Caner V, Buyukpinarbasili N et al (2011) Determination of O(6)-methylguanine DNA methyltransferase promoter methylation in non-small cell lung cancer. Genet Test Mol Biomark 15:357–360

    Article  CAS  Google Scholar 

  14. Vural B, Yakar F, Derin D et al (2012) Evaluation of glutathione S-transferase P1 polymorphisms (Ile105Val and Ala114Val) in patients with small cell lung cancer. Genet Test Mol Biomark 16:701–706

    Article  CAS  Google Scholar 

  15. Dai X, Liu Z, Ren J et al (2011) Association between insulin-like growth factor binding protein-3 promoter polymorphism of −1590C>A and lung cancer susceptibility in a Chinese Han population. Genet Test Mol Biomark 15:301–306

    Article  CAS  Google Scholar 

  16. Devic Pavlic S, Ristic S, Flego V et al (2012) Angiotensin-converting enzyme insertion/deletion gene polymorphism in lung cancer patients. Genet Test Mol Biomark 16:722–725

    Article  CAS  Google Scholar 

  17. Bayramoglu A, Gunes HV, Metintas M et al (2009) The association of MMP-9 enzyme activity, MMP-9 C1562T polymorphism, and MMP-2 and -9 and TIMP-1, -2, -3, and -4 gene expression in lung cancer. Genet Test Mol Biomark 13:671–678

    Article  CAS  Google Scholar 

  18. Jiang B, Zhu ZZ, Liu F et al (2011) STAT3 gene polymorphisms and susceptibility to non-small cell lung cancer. Genet Mol Res 10:1856–1865

    Article  PubMed  CAS  Google Scholar 

  19. Yang L, Shi GL, Song CX et al (2010) Relationship between genetic polymorphism of MCP-1 and non-small-cell lung cancer in the Han nationality of North China. Genet Mol Res 9:765–771

    Article  PubMed  CAS  Google Scholar 

  20. Zhan P, Wang Q, Qian Q et al (2011) CYP1A1 MspI and exon7 gene polymorphisms and lung cancer risk: an updated meta-analysis and review. J Exp Clin Cancer Res 30:99

    Article  PubMed  CAS  Google Scholar 

  21. Ji YN, Zhan P, Wang J et al (2011) APE1 Asp148Glu gene polymorphism and lung cancer risk: a meta-analysis. Mol Biol Rep 38:4537–4543

    Article  PubMed  CAS  Google Scholar 

  22. Feng Z, Ni Y, Dong W et al (2012) Association of ERCC2/XPD polymorphisms and interaction with tobacco smoking in lung cancer susceptibility: a systemic review and meta-analysis. Mol Biol Rep 39:57–69

    Article  PubMed  CAS  Google Scholar 

  23. Shih CM, Chen CY, Lee IH et al (2010) A polymorphism in the hMLH1 gene (−93G–>A) associated with lung cancer susceptibility and prognosis. Int J Mol Med 25:165–170

    PubMed  CAS  Google Scholar 

  24. Aksoy-Sagirli P, Cakmakoglu B, Isbir T et al (2011) Paraoxonase-1 192/55 polymorphisms and the risk of lung cancer in a Turkish population. Anticancer Res 31:2225–2229

    PubMed  CAS  Google Scholar 

  25. Zhou Y, Li N, Zhuang W et al (2007) p53 codon 72 polymorphism and gastric cancer: a meta-analysis of the literature. Int J Cancer 121:1481–1486

    Article  PubMed  CAS  Google Scholar 

  26. Zhou Y, Li N, Zhuang W et al (2010) p53 codon 72 polymorphism and gastric cancer risk in a Chinese Han population. Genet Test Mol Biomark 14:829–833

    Article  CAS  Google Scholar 

  27. Song HR, Kweon SS, Kim HN et al (2011) p53 codon 72 polymorphism in patients with gastric and colorectal cancer in a Korean population. Gastric Cancer 14:242–248

    Article  PubMed  Google Scholar 

  28. Liu KJ, Qi HZ, Yao HL et al (2012) An updated meta-analysis of the p53 codon 72 polymorphism and gastric cancer risk. Mol Biol Rep 39:8265–8275

    Article  PubMed  CAS  Google Scholar 

  29. Zhang R, Chen W, Zhang W et al (2011) Genetic polymorphisms of p53 codon 72 and bladder cancer susceptibility: a hospital-based case-control study. Genet Test Mol Biomark 15:337–341

    Article  CAS  Google Scholar 

  30. Li DB, Wei X, Jiang LH et al (2010) Meta-analysis of epidemiological studies of association of P53 codon 72 polymorphism with bladder cancer. Genet Mol Res 9:1599–1605

    Article  PubMed  CAS  Google Scholar 

  31. Gu Y, Zhou X, Zhang SL (2011) Meta-analysis of an association of codon 72 polymorphisms of the p53 gene with increased endometrial cancer risk. Genet Mol Res 10:3609–3619

    Article  PubMed  CAS  Google Scholar 

  32. Zhang Z, Wang M, Wu D et al (2010) P53 codon 72 polymorphism contributes to breast cancer risk: a meta-analysis based on 39 case-control studies. Breast Cancer Res Treat 120:509–517

    Article  PubMed  CAS  Google Scholar 

  33. Liu Y, Qin H, Zhang Y et al (2011) P53 codon 72 polymorphism and colorectal cancer: a meta-analysis of epidemiological studies. Hepatogastroenterology 58:1926–1929

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Thoracic Surgery, The 2nd Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin, 150086, Heilongjiang, China

    Dazhong Liu, Fei Wang, Xiaotong Guo, Qiushi Wang, Wei Wang, Hao Xu & Guangquan Xu

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  1. Dazhong Liu
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  2. Fei Wang
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  3. Xiaotong Guo
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  4. Qiushi Wang
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  5. Wei Wang
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  6. Hao Xu
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  7. Guangquan Xu
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Correspondence to Guangquan Xu.

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Liu, D., Wang, F., Guo, X. et al. Association between p53 codon 72 genetic polymorphisms and tobacco use and lung cancer risk in a Chinese population. Mol Biol Rep 40, 645–649 (2013). https://doi.org/10.1007/s11033-012-2103-0

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  • DOI: https://doi.org/10.1007/s11033-012-2103-0

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