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Association Between p53 codon 72 Genetic Polymorphism and Tobacco Use and Lung Cancer Risk

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Abstract

Lung cancer (LCa) is the leading cause of death by cancer in men. Genetic and environmental factors play a synergistic role in its etiology. We explore in 111 lung cancer cases and 133 unrelated noncancer controls the gene-environment interaction (G × E) between p53cd72 polymorphism variants and smoking and the effect on LCa risk in two kinds of case-control designs. We assessed the interaction odds ratio (IOR) using an adjusted unconditional logistic model. We found a significant and positive interaction association between Pro* allele carriers and smoking habits in both case-control and case-only designs: IOR = 3.90 (95% confidence interval [CI] = 1.10–13.81) and 3.05 (95% CI = 1.63–5.72), respectively. These exploratory results suggest a synergistic effect of the smoking habit and the susceptibility of the Pro allele on lung cancer risk compared with each risk factor alone.

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Acknowledgments

The National Fund of Scientific Development and Technology (FONDECYT) (Grant No. 2990019) supported this work. Dr. Dante Cáceres thanks Dr. Nevin Schrimshaw and the Ellison Medical Foundation-International Nutrition Foundation.

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Authors and Affiliations

  1. Epidemiology Division, School of Public Health, Faculty of Medicine, University of Chile, Independencia 939, P.O. Box 8380453, Santiago, Chile

    Dante D. Cáceres

  2. Molecular and Clinical Pharmacology Program, IFT, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile

    Luis A. Quiñones

  3. Department of Epidemiology, Gillings School of Public Health, North Carolina University at Chapel Hill, CB #7435, Chapel Hill, NC, 27599, USA

    Jane C. Schroeder

  4. Laboratory of Environmental Toxicology, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile

    Leonel D. Gil

  5. Department of Molecular and Integrative Physiology, Faculty of Medicine, Los Andes University, Santiago, Chile

    Carlos E. Irarrázabal

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  1. Dante D. Cáceres
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  2. Luis A. Quiñones
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  3. Jane C. Schroeder
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Correspondence to Dante D. Cáceres.

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Cáceres, D.D., Quiñones, L.A., Schroeder, J.C. et al. Association Between p53 codon 72 Genetic Polymorphism and Tobacco Use and Lung Cancer Risk. Lung 187, 110–115 (2009). https://doi.org/10.1007/s00408-008-9133-3

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  • DOI: https://doi.org/10.1007/s00408-008-9133-3

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