Abstract
P53 is a tumor suppressor gene and plays important roles in the etiology of breast cancer. Studies revealing conflicting results on the role of p53 codon 72 polymorphism (G>C) on breast cancer risk led us to perform a meta-analysis to investigate this relationship. Thirty-nine published studies, including 26,041 breast cancer cases and 29,679 controls were identified. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the associations. The overall results suggested that the variant genotypes were associated with a significantly reduced breast cancer risk (GC vs. GG: OR = 0.91, 95% CI: 0.83–1.00; CC/GC vs. GG: OR = 0.90, 95% CI: 0.82–0.99). In the stratified analyses, significantly decreased risks were also found among European populations (GC vs. GG: OR = 0.89, 95% CI: 0.80–0.99; CC/GC vs. GG: OR = 0.88, 95% CI: 0.80–0.98) and studies with population-based controls (GC vs. GG: OR = 0.88, 95% CI: 0.78–0.98; CC/GC vs. GG: OR = 0.87, 95% CI: 0.78–0.97). The results suggested that p53 codon 72 polymorphism may contribute to susceptibility to breast cancer, especially in Europeans. Additional well-designed large studies were required to validate this association in different populations.
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Acknowledgments
This study was partly supported by the National Natural Science Foundation of China (30571583, 30800926 and 30872084), the Ph.D. Programs Foundation of Ministry of Education of China (20060312002), the Natural Science Foundation of Jiangsu Province (BK2006231), the Key Program for Basic Research of Jiangsu Provincial Department of Education (08KJA330001) and “Qinglan Project” Foundation for the Young Academic Leader of Jiangsu Province (2006).
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Zhang, Z., Wang, M., Wu, D. et al. P53 codon 72 polymorphism contributes to breast cancer risk: a meta-analysis based on 39 case–control studies. Breast Cancer Res Treat 120, 509–517 (2010). https://doi.org/10.1007/s10549-009-0480-4
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DOI: https://doi.org/10.1007/s10549-009-0480-4