Abstract
To derive a more precise estimation of the relationship between miR-149 C>T polymorphism and cancer risk, a meta-analysis was performed. A total of 8 studies including 4,677 cases and 4,830 controls were involved in this meta-analysis. Overall, no significantly elevated cancer risk was associated with miR-149 T allele when all studies were pooled into the meta-analysis (CT vs. CC: OR = 0.977, 95 % CI = 0.882–1.082; TT vs. CC: OR = 0.985, 95 % CI = 0.857–1.132; dominant model: OR = 0.984, 95 % CI = 0.893–1.084; recessive model: OR = 1.026, 95 % CI = 0.931–1.132). In the subgroup analysis by ethnicity or study design, no significantly increased risks were found under all models. When stratified by cancer type, there were no significant cancer risk changes for lung cancer, breast cancer or colorectal cancer when miR-149 T allele was included. In conclusion, this meta-analysis suggests that the miR-149 C>T polymorphism may not contribute to cancer susceptibility.
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This research was supported by grants from the National Natural Science Foundation of China (81101499), Shanghai Natural Science Foundation (11ZR1407600), and Fudan University Science Foundation for Young Scholars (09FQ76).
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Jian Zhang and Yan-fei Liu contributed equally to this study.
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11033_2012_1735_MOESM1_ESM.jpg
Supplementary files. Figure 1 Forest plots for the association between miR-149 C/T (rs2292832) polymorphism and cancer risk. a CT vs. CC analysis. b TT vs. CC analysis. c dominant model analysis. d recessive model analysis. (JPEG 229 kb)
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Zhang, J., Liu, Yf. & Gan, Y. Lack of association between miR-149 C>T polymorphism and cancer susceptibility: a meta-analysis based on 4,677 cases and 4,830 controls. Mol Biol Rep 39, 8749–8753 (2012). https://doi.org/10.1007/s11033-012-1735-4
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DOI: https://doi.org/10.1007/s11033-012-1735-4