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Intracerebroventricular injection of resveratrol ameliorated Aβ-induced learning and cognitive decline in mice

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Abstract

Resveratrol (RSV) is a natural plant polyphenol compound which consists in red grape skins and wine in general. Plenty of previous studies have shown that resveratrol has neuroprotective effects. The primary object of this research was to study the effects of RSV on improving the cognitive function and neurodegeneration in the mouse model of Alzheimer’s disease induced by Aβ1–42, and the possible mechanism about targeting on Sirt1, which results in attenuating inflammatory response and mitochondrial dysfunction. We established the AD model of intracerebroventricular (i.c.v.) injection of Aβ1–42 and it was observed that the significant decrease in alternately of Y Maze and the quadrant dwell time percentage of Morris water maze test. Furthermore, there were significant upregulations of AMPK/ PGC-1α and downregulations of NF-κB/ IL-1β/ NLRP3 signaling pathways in the hippocampus and prefrontal cortex in AD mice. The treatments with RSV and Donepezil could significantly ameliorate all the behavioral and biochemical changes induced by Aβ1–42. It also noticeably improved the histopathological changes in the hippocampus and cortex. The results suggested that RSV might protect against cognitive deficits and neurodegeneration induced by Aβ1–42, and serve as a potential agent in treatment of AD.

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Acknowledgements

This research was supported by National Natural Science Foundation of China (No. 81573580), Key Laboratory of Polysaccharide Bioactivity Evaluation of TCM of Liaoning Province and Key Laboratory of Quality Control of TCM of Liaoning Province (17-137-1-00).

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Author notes

  1. Yu Qi and Lei Shang contributed equally to this work

Authors and Affiliations

  1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang, 110016, China

    Yu Qi, Zhengzheng Liao, Hang Su, Huiting Jing & Bo Wu

  2. School of Basic Medical Sciences, Shenyang Medical College, Huanghe North Street 146, Shenyang, 110034, China

    Lei Shang

  3. School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road 103, Shengyang, 110016, China

    Kaishun Bi

  4. School of Functional Food and Wine, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang, 110016, China

    Ying Jia

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  1. Yu Qi
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Correspondence to Ying Jia.

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Qi, Y., Shang, L., Liao, Z. et al. Intracerebroventricular injection of resveratrol ameliorated Aβ-induced learning and cognitive decline in mice. Metab Brain Dis 34, 257–266 (2019). https://doi.org/10.1007/s11011-018-0348-6

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  • DOI: https://doi.org/10.1007/s11011-018-0348-6

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