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A new technique for labeling of [11C]-choline, a positron-emitting tracer for tumor imaging

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Summary

[11C]-choline has been reported as a potential tracer for imaging a variety of human tumors with positron emission tomography (PET). A new labeling technique for [11C]-choline was established depending on parameters optimized, such as reaction time, volume, temperature, and the quantity of DMAE.The synthesis yield was improved from 82.0% to 96.5% (EOB), while the consumption of DMAE precursor decreased from 60 to 2 mg. Absolute yield of [11C]-choline was 2500 MBq for a 10-minute irradiation at15mA, and a total synthesis time of less than 8 minutes from [11C]-CH3I to [11C]-choline.

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Authors and Affiliations

  1. Department of Chemistry, Normal University; PET Center, PLA General Hospital, 100875, Beijing, P.R. China; 100853, Beijing, P.R. China

    Zhang Jinming

  2. PET Center, PLA General Hospital, 100853, Beijing, P.R. China

    Tian Jiahe

  3. Department of Chemistry, Normal University, 100875, Beijing, P.R. China

    Wang Wushang

  4. Department of Chemistry, Normal University, 100875, Beijing, P.R. China

    Liu Baoli

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  1. Zhang Jinming
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  2. Tian Jiahe
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  3. Wang Wushang
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  4. Liu Baoli
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Jinming, Z., Jiahe, T., Wushang, W. et al. A new technique for labeling of [11C]-choline, a positron-emitting tracer for tumor imaging. J Radioanal Nucl Chem 267, 665–668 (2006). https://doi.org/10.1007/s10967-006-0100-2

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  • DOI: https://doi.org/10.1007/s10967-006-0100-2

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