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A novel strategy for the preparation of the injectable PET/CT radiopharmaceutical (-)-[11C]-(1R,2S)-meta-hydroxyephedrine ((-)-[11C]HED

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Abstract

Positron emission tomography (PET) had been applied in clinical early diagnosis of various tumors and other diseases. The methylated synthetic conditions of (-)-[11C]-(1R,2S)-meta-hydroxyephedrine ((-)-[11C]HED), considered as one of the most important radiopharmaceuticals for PET, were optimized through single factor and orthogonal design methods. Here, we reported an improved purification protocol. The radiochemical yields of the final product were over 45% (decay-corrected and based on [11C]methyl iodide) (n = 50). The radiochemical purities and chemical purities were over 99% (n = 50) and 97% (n = 50), respectively. The automatic radiosynthesis procedure of (-)-[11C]HED with relatively high radiochemical yield was convenient and reliable.

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Acknowledgements

This work was supported by the fund of National Key Clinical Specialty Project.

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Author notes

  1. Lei Liu and Xiaobo Li have contributed equally and should be considered as co-first authors.

Authors and Affiliations

  1. PET-CT Diagnostic Department, General Hospital of Tianjin Medical University, 154 Anshan Rd., Heping District, Tianjin, 300052, China

    Lei Liu, Yansheng Li, Haonan Yu & Qiusong Chen

  2. Laboratory of Epigenetics and Tumorigenesis, Tianjin Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China

    Xiaobo Li

  3. Division of Hematology/Oncology, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA, 30322, USA

    Xiaobo Li & Lei Dong

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  1. Lei Liu
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Correspondence to Qiusong Chen.

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Liu, L., Li, X., Dong, L. et al. A novel strategy for the preparation of the injectable PET/CT radiopharmaceutical (-)-[11C]-(1R,2S)-meta-hydroxyephedrine ((-)-[11C]HED. J Radioanal Nucl Chem 320, 543–549 (2019). https://doi.org/10.1007/s10967-019-06534-5

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