Skip to main content

Advertisement

SpringerLink
Log in

Polymer-based hydrogel scaffolds for skin tissue engineering applications: a mini-review

  • REVIEW PAPER
  • Published:
Journal of Polymer Research Aims and scope Submit manuscript

Abstract

Polymer hydrogels consist of a three-dimensional (3D) structure with cross-linked networks rich in a huge amount of water through hydrogen-bonding interactions, making them highly hydrophilic. Due to their impressive hydrophilic characteristics and cell non-cytotoxicity, polymer hydrogels are useful tissue engineering tools for the organization of cells and tissues and organ regeneration. Many biomedical engineers and researchers have recently begun to utilize polymer hydrogels as tissue or cell culture environments and as scaffolds for the stable growth of organs in tissue engineering and regeneration medicine. This paper focuses on skin regeneration in polymer hydrogels where skin is a means of protecting the body from infection or physical or chemical damage. Generally, skin tissue that has incurred minor damage or wounds can regenerate and heal in a relatively short time, while severe injuries may require transplantation or artificial skin. For those purposes, skin culturing in an in vitro environment is essential, and the environment produced using polymer hydrogel scaffolds needs to be both similar to the real environment and safe for skin cell growth. This paper reviews post-2000 skin regeneration research in the field of tissue engineering, focusing specifically on polymer hydrogels; it also discusses some of the central perspectives and key issues.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Kim TG, Shin H, Lim DW (2012) Adv Funct Mater 22:2446–2468

    Article  CAS  Google Scholar 

  2. Metcalfe AD, Ferguson MW (2007) Biomaterials 28:5100–5113

    Article  CAS  Google Scholar 

  3. Slaughter BV, Khurshid SS, Fisher OZ, Khademhosseini A, Peppas NA (2009) Adv Mater 21:3307–3329

    Article  CAS  Google Scholar 

  4. Huynh CT, Lee DS (2012) Colloid Polym Sci 290:1077–1086

    Article  CAS  Google Scholar 

  5. El-Sherbiny IM, Yacoub MH (2013) Glob Cardiol Sci Pract 3:316–342

    Google Scholar 

  6. Rice JJ, Martino MM, De Laporte L, Tortelli F, Briquez PS, Hubbell JA (2013) Adv Healthc Mater 2:57–71

    Article  CAS  Google Scholar 

  7. Wolf MT, Daly KA, Brennan-Pierce EP, Johnson SA, Carruthers CA, D'Amore A, Nagarkar SP, Velankar SS, Badylak SF (2012) Biomaterials 33:7028–7038

    Article  CAS  Google Scholar 

  8. Hynes RO (2002) Cell 110:673–687

    Article  CAS  Google Scholar 

  9. Michel G, Tonon T, Scornet D, Cock JM, Kloareg B (2010) New Phytol 188:82–97

    Article  CAS  Google Scholar 

  10. Lee KY, Jeong L, Kang YO, Lee SJ, Park WH (2009) Adv Drug Deliv Rev 61(2009):1020–1032

    Article  CAS  Google Scholar 

  11. Abedin M, King N (2010) Trends Cell Biol 20:734–742

    Article  CAS  Google Scholar 

  12. Faulk DM, Londono R, Wolf MT, Ranallo CA, Carruthers CA, Wildemann JD, Dearth CL, Badylak SF (2014) Biomaterials 35:8585–8595

    Article  CAS  Google Scholar 

  13. Herbst RS (2004) Int J Radiat Oncol Biol Phys 59:21–26

    Article  CAS  Google Scholar 

  14. Doma E, Rupp C, Baccarini M (2013) Int J Mol Sci 14:19361–19384

    Article  Google Scholar 

  15. Norouzi M, Shabani I, Ahvaz HH, Soleimani M (2014) J Biomed Mater Res A 103:2225–2235

    Article  Google Scholar 

  16. Ching YH, Sutton TL, Pierpont YN, Robson MC, Payne WG (2011) Eplasty 11:e41

    Google Scholar 

  17. Yoo YH, Kim YR, Kim MS, Lee K-J, Park KH, Hahn J-H (2014) BMB Rep 47(2014):581–586

    Article  CAS  Google Scholar 

  18. Radhakrishnan J, Krishnan UM, Sethuraman S (2014) Biotechnol Adv 32:449–461

    Article  CAS  Google Scholar 

  19. Wetterau M, George F, Weinstein A, Nguyen PD, Tutela JP, Knobel D, Cohen O, Warren SM, Saadeh PB (2011) Wound Repair Regen 19:481–486

    Article  Google Scholar 

  20. Thandavarayan RA, Garikipati VN, Joladarashi D, Babu SS, Jeyabal P, Verma SK, Mackie AR, Khan M, Arumugam S, Watanabe K, Kishore R, Krishnamurthy P (2015) Exp Dermatol 24:773–778

    Article  CAS  Google Scholar 

  21. Vandegrift MT, Szpalski C, Knobel D, Weinstein A, Ham M, Ezeamuzie O, Warren SM, Saadeh PB (2015) J Surg Res 195:360–367

    Article  CAS  Google Scholar 

  22. Yildirimer L, Thanh NT, Seifalian AM (2011) Trends Biotechnol 30:638–648

    Article  Google Scholar 

  23. Zorlutuna P, Annabi N, Camci-Unal G, Nikkhah M, Cha JM, Nichol JW, Manbachi A, Bae H, Chen S, Khademhosseini A (2012) Adv Mater 24:782–1804

    Article  Google Scholar 

  24. Lee W, Debasitis JC, Lee VK, Lee JH, Fischer K, Edminster K, Park JK, Yoo SS (2009) Biomaterials 30:1587–1595

    Article  CAS  Google Scholar 

  25. Billiet T, Vandenhaute M, Schelfhout J, Van Vlierberghe S, Dubruel P (2012) Biomaterials 33:6020–6041

    Article  CAS  Google Scholar 

  26. Butcher AL, Offeddu GS, Oyen ML (2014) Trends Biotechnol 32:564–570

    Article  CAS  Google Scholar 

  27. Reddy VJ, Radhakrishnan S, Ravichandran R, Mukherjee S, Balamurugan R, Sundarrajan S, Ramakrishna S (2013) Wound Repair Regen 21:1–16

    Article  Google Scholar 

  28. Dhandayuthapani B, Krishnan UM, Sethuraman S (2010) J Biomed Mater Res B Appl Biomater 94:264–272

    Google Scholar 

  29. Zhou F-L, Gong R-H (2008) Polym Int 57:837–845

    Article  CAS  Google Scholar 

  30. Xie Z, Para CB, Weng H, Punnakitikashem P, Su L-C, Vu K, Tang L, Yang J, Nguyen KT (2013) Acta Biomater 9:9351–9359

    Article  CAS  Google Scholar 

  31. Ferreira LS, Gerecht S, Fuller J, Shieh HF, Vunjak-Novakovic G, Langer R (2007) Biomaterials 28:2706–2717

    Article  CAS  Google Scholar 

  32. Verhulsel M, Vignes M, Descroix S, Malaquin L, Vignjevic DM, Viovy JL (2014) Biomaterials 35:1816–1832

    Article  CAS  Google Scholar 

  33. Pati F, Ha DH, Jang J, Han HH, Rhie JW, Cho DW (2015) Biomaterials 62:164–175

    Article  CAS  Google Scholar 

  34. Das S, Pati F, Choi YJ, Rijal G, Shim JH, Kim SW, Ray AR, Cho DW, Ghosh S (2015) Acta Biomater 11:233–246

    Article  CAS  Google Scholar 

  35. Pereira R, Carvalho A, Vaz DC, Gil MH, Mendes A, Bartolo P (2013) Int J Biol Macromol 52:221–230

    Article  CAS  Google Scholar 

  36. Thu HE, Zulfakar MH, Ng SF (2012) Int J Pharm 434:375–383

    Article  CAS  Google Scholar 

  37. Pereira R, Mendes A, Bártolo P (2013) Procedia CIRP 5:210–215

    Article  Google Scholar 

  38. Di Lullo GA, Sweeney SM, Korkko J, Ala-Kokko L, San Antonio JD (2002) J Biol Chem 277:4223–4231

    Article  Google Scholar 

  39. Gennero L, De Siena R, Denysenko T, Roos MA, Calisti GF, Martano M, Fiobellot S, Panzone M, Reguzzi S, Gabetti L, Vercelli A, Cavallo G, Ricci E, Pescarmona GP (2011) Cell Biochem Funct 29:311–333

    Article  CAS  Google Scholar 

  40. Rnjak J, Li Z, Maitz PK, Wise SG, Weiss AS (2009) Biomaterials 30:6469–6477

    Article  CAS  Google Scholar 

  41. Wehrhan F, Nkenke E, Melnychenko I, Amann K, Schlegel KA, Goerlach C, Zimmermann WH, Schultze-Mosgau S (2010) Dermatol Surg 36:919–930

    Article  CAS  Google Scholar 

  42. Chan TR, Stahl PJ, Li Y, Yu SM (2015) Acta Biomater 15:164–172

    Article  CAS  Google Scholar 

  43. Mazaki T, Shiozaki Y, Yamane K, Yoshida A, Nakamura M, Yoshida Y, Zhou D, Kitajima T, Tanaka M, Ito Y, Ozaki T, Matsukawa A (2014) Sci Rep 4:4457

    Article  Google Scholar 

  44. Jimenez RA, Millan D, Suesca E, Sosnik A, Fontanilla MR (2015) Drug Deliv Transl Res 5:209–218

    Article  CAS  Google Scholar 

  45. Yamada S, Yamamoto K, Ikeda T, Yanagiguchi K, Hayashi Y (2014) Biomed Res Int 2014:302932

    Article  Google Scholar 

  46. Fakhari A, Berkland C (2013) Acta Biomater 9:7081–7092

    Article  CAS  Google Scholar 

  47. Lam J, Truong NF, Segura T (2014) Acta Biomater 10:1571–1580

    Article  CAS  Google Scholar 

  48. Lee Y-C, Lee K, Hwang Y, Andersen HR, Kim B, Lee SY, Choi M-H, Park J-Y, Han Y-K, Oh Y-K, Huh YS (2014) RSC Adv 4:4122–4127

    Article  CAS  Google Scholar 

  49. Ribeiro MP, Espiga A, Silva D, Baptista P, Henriques J, Ferreira C, Silva JC, Borges JP, Pires E, Chaves P, Correia IJ (2009) Wound Repair Regen 17:817–824

    Article  Google Scholar 

  50. Mohd Hilmi AB, Halim AS, Jaafar H, Asiah AB, Hassan A (2013) Biomed Res Int 2013:795458

    Article  Google Scholar 

  51. Haifei S, Xingang W, Shoucheng W, Zhengwei M, Chuangang Y, Chunmao H (2014) J Mech Behav Biomed Mater 29:114–125

    Article  Google Scholar 

  52. Boucard N, Viton C, Agay D, Mari E, Roger T, Chancerelle Y, Domard A (2007) Biomaterials 28:3478–3488

    Article  CAS  Google Scholar 

  53. Wang X, You C, Hu X, Zheng Y, Li Q, Feng Z, Sun H, Gao C, Han C (2013) Acta Biomater 9:7822–7832

    Article  CAS  Google Scholar 

  54. Morgado PI, Lisboa PF, Ribeiro MP, Miguel SP, Simões PC, Correia IJ, Aguiar-Ricardo A (2014) J Membr Sci 469:262–271

    Article  CAS  Google Scholar 

  55. Zulkifli FH, Hussain FS, Rasad MS, Yusoff MM (2014) Carbohydr Polym 114:238–245

    Article  CAS  Google Scholar 

  56. Hartwell R, Leung V, Chavez-Munoz C, Nabai L, Yang H, Ko F, Ghahary A (2011) Acta Biomater 7:3060–3069

    Article  CAS  Google Scholar 

  57. Shalumon KT, Anulekha KH, Nair SV, Chennazhi KP, Jayakumar R (2011) Int J Biol Macromol 49:247–254

    Article  CAS  Google Scholar 

  58. Zhu J (2010) Biomaterials 31:4639–4656

    Article  CAS  Google Scholar 

  59. Song A, Rane AA, Christman KL (2012) Acta Biomater 8:41–50

    Article  CAS  Google Scholar 

  60. Chen SH, Tsao CT, Chang CH, Lai YT, Wu MF, Chuang CN, Chou HC, Wang CK, Hsieh KH (2013) Mater Sci Eng C Mater Biol Appl 33:2584–2594

    Article  CAS  Google Scholar 

  61. Sargeant TD, Desai AP, Banerjee S, Agawu A, Stopek JB (2012) Acta Biomater 8:124–132

    Article  CAS  Google Scholar 

  62. Swartzlander MD, Lynn AD, Blakney AK, Kyriakides TR, Bryant SJ (2013) Biomaterials 34:952–964

    Article  CAS  Google Scholar 

  63. Labet M, Thielemans W (2009) Chem Soc Rev 38:3484–3504

    Article  CAS  Google Scholar 

  64. Venugopal J, Ma LL, Ramakrishna S (2005) Tissue Eng 11:847–854

    Article  CAS  Google Scholar 

  65. Dai NT, Williamson MR, Khammo N, Adams EF, Coombes AG (2004) Biomaterials 25:4263–4271

    Article  CAS  Google Scholar 

  66. Cai EZ, Teo EY, Jing L, Koh YP, Qian TS, Wen F, Lee JW, Hing EC, Yap YL, Lee H, Lee CN, Teoh SH, Lim J, Lim TC (2014) Arch Plast Surg 41:638–646

    Article  Google Scholar 

  67. Prasad T, Shabeena EA, Vinod D, Kumary TV, Anil Kumar PR (2015) J Mater Sci 26:5352

    Google Scholar 

  68. Gong Y, Zhou Q, Gao C, Shen J (2007) Acta Biomater 3:531–540

    Article  CAS  Google Scholar 

  69. Santos AR, Barbanti SH, Duek EAR, Dolder H, Wada RS, Wada MLF (2001) Artif Organs 25:7–13

    Article  CAS  Google Scholar 

  70. Hurtado A, Cregg JM, Wang HB, Wendell DF, Oudega M, Gilbert RJ, McDonald JW (2011) Biomaterials 32:6068–6079

    Article  CAS  Google Scholar 

  71. MacNeil S (2007) Nature 445:874–880

    Article  CAS  Google Scholar 

  72. Metcalfe AD, Ferguson MW (2007) J R Soc Interface 4:413–437

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (NRF-2014R1A1A2055916) and by the “Korean Environmental Industry & Technology Institute” (KEITI) (NO.2015000120002) of the Ministry of the Environment.

Author information

Authors and Affiliations

  1. Department of BioNano Technology, Gachon University, 1342 Seongnamdaero, Sujeong-gu, Seongnam-si, Gyeonggi-do, 13120, Republic of Korea

    Kwang-Hun Jeong & Young-Chul Lee

  2. Environmental Safety Group, Korea Institute of Science and Technology – Europe (KIST-Europe) Forschungsgesellschaft mBH, Campus E7. 1, 66123, Saarbrücken, Germany

    Kwang-Hun Jeong

  3. Department of Biomedical Engineering, University of Science and Technology (UST), 217 Gajeong-ro, Yuseong-gu, Daejeon, 34113, Republic of Korea

    Kwang-Hun Jeong

  4. Korea Railroad Research Institute (KRRI), 176 Cheoldobakmulkwan-ro, Uiwang-si, Gyeonggi-do, 16105, Republic of Korea

    Duckshin Park

Authors
  1. Kwang-Hun Jeong
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Duckshin Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Young-Chul Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Young-Chul Lee.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jeong, KH., Park, D. & Lee, YC. Polymer-based hydrogel scaffolds for skin tissue engineering applications: a mini-review. J Polym Res 24, 112 (2017). https://doi.org/10.1007/s10965-017-1278-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s10965-017-1278-4

Keywords

Search

Navigation