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A facile synthesis of hydrophilic glycopolymers with the ether linkages throughout the main chains

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Abstract

A series of well-defined block glycopolymer with the ether linkages throughout the main chains were synthesized by an easy and efficient way. First, the block copolymer intermediates poly(ethylene oxide)-b-poly(allyl glycidyl ether) (PEO-b-PAGE) with narrow molecular weight distribution were prepared by living anionic ring-opening polymerization. Then, 2,3,4,6-tetra-O-acetyl-β-thioglucopyranose (AcGSH) molecules were attached to the PAGE blocks by free-radical addition reaction of –SH groups of saccharide molecules with the double bonds. Finally, removal of the acetyl protective groups afforded the corresponding glycopolymers poly(ethylene oxide)-b-poly(allyl glycidyl ether-glucose) (PEO-b-P(AGE-glucose)). The composition and structure of the glycopolymers were characterized by 1HNMR, 13CNMR and FT-IR.

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Acknowledgements

We are thankful the financial support from the National Natural Science Foundation of China (No 20473026).

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Authors and Affiliations

  1. College of Chemistry & Environmental science, Henan Normal University, Xinxiang, 453007, Henan, People’s Republic of China

    Zhiguo Hu, Xiaoshan Fan, Jianxin Wang, Shuping Zhao & Xiaoliang Han

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  1. Zhiguo Hu
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  2. Xiaoshan Fan
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  3. Jianxin Wang
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  4. Shuping Zhao
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  5. Xiaoliang Han
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Correspondence to Zhiguo Hu.

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Hu, Z., Fan, X., Wang, J. et al. A facile synthesis of hydrophilic glycopolymers with the ether linkages throughout the main chains. J Polym Res 17, 815–820 (2010). https://doi.org/10.1007/s10965-009-9372-x

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