Abstract
Glycopolypeptides are prepared either by the polymerization of glycosylated amino acid N-carboxyanhydrides (NCAs) or by the post-polymerization functionalization of polypeptides with suitable functional groups. Here we present a method for the in-situ functionalization and (co-) polymerization of allylglycine N-carboxyanhydride in a facile one-pot procedure, combining radical thiol-ene photochemistry and nucleophilic ring-opening polymerization techniques, to yield well-defined heterofunctional glycopolypeptides.
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Acknowledgment
Financial support was given by the Max Planck Society and the German Research Foundation (within the IUPAC Transnational Pilot Call in Polymer Chemistry).
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Krannig, KS., Schlaad, H. (2016). Heterofunctional Glycopolypeptides by Combination of Thiol-Ene Chemistry and NCA Polymerization. In: Sun, XL. (eds) Macro-Glycoligands. Methods in Molecular Biology, vol 1367. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3130-9_6
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DOI: https://doi.org/10.1007/978-1-4939-3130-9_6
Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-3129-3
Online ISBN: 978-1-4939-3130-9
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