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Magnetic Nanocrystalline Cellulose: Azithromycin Adsorption and In Vitro Biological Activity Against Melanoma Cells

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Abstract

This study reports a simple methodology of obtaining magnetic nanocrystalline cellulose under very mild conditions employing only Fe2+ as the iron source, enabling the control of the amount Fe3O4 incorporated. Magnetic nanocomposites were characterized by FTIR, XRD, SEM, and Raman techniques. The adsorption results showed that the maximum of AZT adsorbed was reached at pH 3.0 using NC‧Fe3O4 1:10. The adsorption efficiency is highly dependent on experimental conditions. Regarding equilibrium and adsorption kinetic, Freundlich and Pseudo-second-order models show the best adjust for the experimental data. Thermodynamic values demonstrated that adsorption is an exothermic process and occurs spontaneously. Magnetic nanoadsorbent proves to be efficient in AZT removal from the aqueous medium, avoiding filtration/centrifugation steps. The in vitro biological assays showed that magnetic nanobiopolymers exhibited biocompatibility and higher toxicity against melanoma cells.

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Acknowledgements

The authors would like to thank FAPERGS, CAPES, Laboratório de Materiais Magnéticos Nanoestruturados (LaMMaN) and Universidade Franciscana (UFN) for the scholarships granted.

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Authors and Affiliations

  1. Laboratório de Materiais Magnéticos Nanoestruturados, LaMMaN, Programa de Pós-Graduação em Nanociências, Santa Maria, Brazil

    Theodoro da Rosa Salles, Franciele da Silva Bruckamann, Sergio Roberto Mortari & Cristiano Rodrigo Bohn Rhoden

  2. Programa de Pós-Graduação em Nanociências, Universidade Franciscana – UFN, Santa Maria, 97010-032, Brazil

    Altevir Rossato Viana

  3. Departamento de Morfologia da Universidade Federal de Santa Maria, Santa Maria, Brazil

    Luciana Maria Fontanari Krause

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  1. Theodoro da Rosa Salles
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  2. Franciele da Silva Bruckamann
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  3. Altevir Rossato Viana
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  4. Luciana Maria Fontanari Krause
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  5. Sergio Roberto Mortari
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  6. Cristiano Rodrigo Bohn Rhoden
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Contributions

TS and FB carried out the adsorption experiments and wrote the manuscript. AV carried out the biological assays. SM and LK perform the data analysis with constructive discussions on the manuscript elaboration. CR provided the novel idea, revised the manuscript writing and supervised the research.

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Correspondence to Cristiano Rodrigo Bohn Rhoden.

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da Rosa Salles, T., da Silva Bruckamann, F., Viana, A.R. et al. Magnetic Nanocrystalline Cellulose: Azithromycin Adsorption and In Vitro Biological Activity Against Melanoma Cells. J Polym Environ 30, 2695–2713 (2022). https://doi.org/10.1007/s10924-022-02388-3

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