Abstract
In this study, a sensitive fluorimetric method is proposed for the determination of piroxicam using nitrogen graphene quantum dots (N-GQDs) and gold nanoparticles coated with phenylalanine. The fluorescence emission of N-GQDs at 440 nm decreases with the increase of gold nanoparticles coated with phenylalanine. However, the addition of piroxicam causes the release of gold nanoparticles from the surface of quantum dots followed by the retrieval of the fluorescence emission of N-GQDs. Under the optimum conditions, the calibration graph was linear in the concentration range of 2.0–35.0 nmol L−1 for piroxicam with a limit of detection of 0.11 nmol L−1. The developed method was successfully applied for the determination of piroxicam in urine and serum samples.
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The datasets generated during and/or analyzed during the current study are not publicly available but are available from the corresponding author on reasonable request.”
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All authors contributed to the study's conception and design. Material preparation, data collection, and analysis were performed by Maryam Moallemi Bahmani, Ali Mohammad Haji Shabani, Shayessteh Dadfarnia, and Roya Afsharipour. The first draft of the manuscript was written by Roya Afsharipour and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Moallemi Bahmani, M., Haji Shabani, A.M., Dadfarnia, S. et al. Selective and Sensitive Fluorometric Determination of Piroxicam Based on Nitrogen-doped Graphene Quantum Dots and Gold Nanoparticles Coated with Phenylalanine. J Fluoresc 32, 1337–1346 (2022). https://doi.org/10.1007/s10895-022-02907-4
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DOI: https://doi.org/10.1007/s10895-022-02907-4