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Selective fluorometric determination of sulfadiazine based on the growth of silver nanoparticles on graphene quantum dots

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Abstract

A sensitive fluorometric assay is described for the direct determination of the antibiotic sulfadiazine. Silver nanoparticles placed on graphene quantum dots (Ag NP-GQDs) were synthesized by reduction of AgNO3 with sodium borohydride in the presence of GQDs. The growth of Ag NPs on the surface of the GQDs causes quenching of the blue fluorescence of the GQDs with an emission maximum at 470 nm by surface-enhanced energy transfer. If sulfadiazine is added, it interacts with Ag NPs and fluorescence is restored. Under optimal conditions, the fluorescence increases linearly in the sulfadiazine concentration range of 0.04–22.0 μM. The detection limit is 10 nM with relative standard deviations of 2.3 and 4.2 (at 10 μM of sulfadiazine; for n = 6) for intra- and inter-day assays.

Schematic representation of sulfadiazine determination using Ag NP-GQDs as a fluorescent nanoprobe.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Yazd University, Yazd 98195-741, Iran

    Roya Afsharipour, Ali Mohammad Haji Shabani & Shayessteh Dadfarnia

  2. Environmental and Bio-Analytical Laboratories, Department of Chemistry, Sharif University of Technology, P.O. Box 11365-9516, Tehran, Iran

    Elahe Kazemi

Authors
  1. Roya Afsharipour
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  2. Ali Mohammad Haji Shabani
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  3. Shayessteh Dadfarnia
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  4. Elahe Kazemi
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Correspondence to Ali Mohammad Haji Shabani or Shayessteh Dadfarnia.

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Afsharipour, R., Haji Shabani, A.M., Dadfarnia, S. et al. Selective fluorometric determination of sulfadiazine based on the growth of silver nanoparticles on graphene quantum dots. Microchim Acta 187, 54 (2020). https://doi.org/10.1007/s00604-019-4001-9

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  • DOI: https://doi.org/10.1007/s00604-019-4001-9

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