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Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 5: Hydrolytically degradable materials

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Abstract

Macroporous hydrogels based on 2-hydroxyethyl methacrylate, 2-ethoxyethyl methacrylate and N-(2-hydroxypropyl)methacrylamide, methacrylic acid and [2-(methacryloyloxy)ethyl]trimethylammonium chloride crosslinked with N,O-dimethacryloylhydroxylamine were prepared. Hydrogels were degraded in a buffer of pH 7.4. Completely water-soluble polymers were obtained over time periods ranging from 2 to 40 days. The process of degradation was followed gravimetrically and by optical and electron microscopy. In vivo biological tests with hydrogels based on copolymers of 2-ethoxyethyl methacrylate/N-(2-hydroxypropyl)methacrylamide were performed.

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Authors and Affiliations

  1. Academy of Sciences of the Czech Republic, Institute of Macromolecular Chemistry, 162 06, Prague 6, Czech Republic

    Martin Přádný, Jiří Michálek, Jiří Vacík & Miroslav Šlouf

  2. Center for Cell Therapy and Tissue Repair, Charles University, 150 06, Prague 5, Czech Republic

    Jiří Michálek, Petr Lesný, Aleš Hejčl, Jiří Vacík & Eva Syková

  3. Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 142 20, Prague 4, Czech Republic

    Petr Lesný, Aleš Hejčl & Eva Syková

Authors
  1. Martin Přádný
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  2. Jiří Michálek
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  3. Petr Lesný
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  4. Aleš Hejčl
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  5. Jiří Vacík
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  6. Miroslav Šlouf
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  7. Eva Syková
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Correspondence to Martin Přádný.

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Přádný, M., Michálek, J., Lesný, P. et al. Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 5: Hydrolytically degradable materials. J Mater Sci: Mater Med 17, 1357–1364 (2006). https://doi.org/10.1007/s10856-006-0611-y

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  • DOI: https://doi.org/10.1007/s10856-006-0611-y

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