Skip to main content
SpringerLink
Log in

Biocompatibility of novel carboxylated graphene oxide–glutamic acid complexes

  • Published:
Journal of Materials Science Aims and scope Submit manuscript

Abstract

The biocompatibility improvement of graphene oxide is crucial for biomedical applications. Herein, we propose to prepare carboxylated graphene oxide (GeneO–COOH) with glutamic acid (Glu) at different pH values. The complexes (GemeO–COOH/Glu) are characterized by FT-IR, XRD, TG, and Zeta potential. The results show that the complexes have close relation with pH value due to the acid-responsive Glu. It is demonstrated that GeneO–COOH complexes with Glu via amidation reaction in the basic domain. The blood compatibility of GeneO–COOH/Glu complexes is evaluated by hemolysis and recalcification test. The results show that the plasma recalcification time is prolonged greatly in the whole blood, and the hemolysis rates are less than 5 %. In a word, GeneO–COOH/Glu complexes are blood compatible at low concentration, which is potential for producing blood-contacting materials.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. Dikin DA, Stankovich S, Zimney EJ, Piner RD, Dommett GB, Evmenenko G, Nguyen ST, Ruoff RS (2007) Nature 448:45

    Article  Google Scholar 

  2. Liang GC, Neophytou N, Lundstrom MS, Nikonov DE (2007) J Appl Phys 102:1

    Google Scholar 

  3. Ishigami M, Chen JH, Cullen WG, Fuhrer MS, Williams ED (2007) Nano Lett 7:1643

    Article  CAS  Google Scholar 

  4. Gilje S, Han S, Wang MS, Wang KL, Kaner RB (2007) Nano Lett 7:3394

    Article  CAS  Google Scholar 

  5. Ferralis N (2010) J Mater Sci 45:5135. doi:10.1007/s10853-010-4673-3

    Article  CAS  Google Scholar 

  6. Chen X, He Y, Zhang Q, Li L, Hu D, Yin T (2010) J Mater Sci 45:953. doi:10.1007/s10853-009-4025-3

    Article  CAS  Google Scholar 

  7. Liu Y, Chen Z, Yang G (2011) J Mater Sci 46:882. doi:10.1007/s10853-010-4829-1

    Article  CAS  Google Scholar 

  8. Zhang Y, Pan C (2011) J Mater Sci 46:2622. doi:10.1007/s10853-010-5116-x

    Article  CAS  Google Scholar 

  9. Lu J, Do I, Drzal LT, Worden RM, Lee I (2008) ACS Nano 2:1825

    Article  CAS  Google Scholar 

  10. Lu J, Drzal LT, Worden RM, Lee I (2007) Chem Mater 19:6240

    Article  CAS  Google Scholar 

  11. Meng N, Zhang SQ, Zhou NL, Shen J (2010) Nanotechnology 21:185101

    Article  Google Scholar 

  12. Bai H, Li C, Wang X, Shi G (2010) Chem Commun 46:2376

    Article  CAS  Google Scholar 

  13. Liu Z, Robinson JT, Sun XM, Dai HJ (2008) J Am Chem Soc 130:10876

    Article  CAS  Google Scholar 

  14. Feng LZ, Zhang S, Liu Z (2011) Nanoscale 3:1252

    Article  CAS  Google Scholar 

  15. Jiang BJ, Tian CG, Song G, Chang W, Wang GF, Wu Q, Fu HG (2013) J Mater Sci 48:1980. doi:10.1007/s10853-012-6964-3

    Article  CAS  Google Scholar 

  16. Stankovich S, Piner RD, Nguyen SBT, Ruoff RS (2006) Carbon 44:3342

    Article  CAS  Google Scholar 

  17. Shao GL, Lu YG, Wu FF, Yang CL, Zeng FL, Wu QL (2012) J Mater Sci 47:4400. doi:10.1007/s10853-012-6294-5

    Article  CAS  Google Scholar 

  18. Wang Y, Xie L, Sha J, Ma Y, Han J, Dong S, Liu H, Fang C, Gong S, Wu Z (2011) J Mater Sci 46:3611. doi:10.1007/s10853-011-5277-2

    Article  CAS  Google Scholar 

  19. Yoon S, In I (2011) J Mater Sci 46:1316. doi:10.1007/s10853-010-4917-2

    Article  CAS  Google Scholar 

  20. Wilson NR, Pandey PA, Beanland R, Young RJ, Kinloch LA, Gong L, Liu Z, Suenaga K, Rourke JP, York SJ, Sloan J (2009) ACS Nano 3:2547

    Article  CAS  Google Scholar 

  21. Rourke JP, Pandey PA, Moore JJ, Bates M, Kinloch IA, Young RJ, Wilson NR (2011) Angew Chem Int Edit 50:3173

    Article  CAS  Google Scholar 

  22. Thomas HR, Valles C, Young RJ, Kinloch IA, Wilson NR, Rourke JP (2013) J Mater Chem C 1:338

    Article  CAS  Google Scholar 

  23. Zhou NL, Meng N, Ma YC, Liao XM, Zhang J, Li L, Shen J (2009) Carbon 47:1343

    Article  CAS  Google Scholar 

  24. Wang XD, Zhou NL, Yuan J, Wang WY, Tang YD, Lu CY, Zhang J, Shen J (2012) J Mater Chem 22:1673

    Article  CAS  Google Scholar 

  25. Cai X, Tan SZ, Lin MS, Xie A, Mai WJ, Zhang XJ, Lin ZD, Wu T, Liu YL (2011) Langmuir 27:7828

    Article  CAS  Google Scholar 

  26. Nakajima T, Matsuo Y (1994) Carbon 32:469

    Article  CAS  Google Scholar 

  27. Pareds JI, Villar-Rodil S (2008) Langmuir 24:10560

    Article  Google Scholar 

  28. Sun X, Liu Z, Welsher K, Robinson JT, Goodwin A, Zaric S, Dai H (2009) NanoRes 1:203

    Google Scholar 

  29. Han YS, Moon JW, Na YH, Park SM (2007) J Ceram Process Res 8:288

    Google Scholar 

  30. Gao LA, Yang F, Liu YQ, Sun J (2010) J Phys Chem C 114:22085

    Article  Google Scholar 

  31. Xu D, Zhou NL, Shen J (2010) Chem J Chin Univ 31:2354

    CAS  Google Scholar 

  32. Dash BC, Réthoré G, Monaghan M, Fitzgerald K, Gallagher W, Pandit A (2010) Biomaterials 31:8188

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by the ninth batch of “six talents of high level talents peak” Funding Scheme (2012-NY-031), the National Natural Science Foundation of China (21274063), the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), Base of production, education & research of prospective joint research project of Jiangsu Province (BY2011109), and Natural Science Foundation of the Jiangsu Higher Education Institutions of China (11KJD430003).

Author information

Authors and Affiliations

  1. Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing Normal University, Nanjing, 210097, China

    Ning-Lin Zhou, Hao Gu, Fei-Fen Tang, Wen-Xiu Li, Yuan-Yuan Chen & Jiang Yuan

  2. Jiangsu Key Laboratory of Biofunctional Materials, Nanjing Normal University, Nanjing, 210097, China

    Ning-Lin Zhou, Hao Gu, Fei-Fen Tang, Wen-Xiu Li, Yuan-Yuan Chen & Jiang Yuan

  3. Jiangsu Technological Research Center for Interfacial Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China

    Ning-Lin Zhou & Jiang Yuan

  4. School of Chemistry and Materials Science, Nanjing Normal University, No.1 Wenyuan Road, Nanjing, 210023, Jiangsu, China

    Ning-Lin Zhou, Fei-Fen Tang, Wen-Xiu Li, Yuan-Yuan Chen & Jiang Yuan

  5. Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Nanjing Normal University, Nanjing, 210097, China

    Ning-Lin Zhou, Fei-Fen Tang, Wen-Xiu Li, Yuan-Yuan Chen & Jiang Yuan

Authors
  1. Ning-Lin Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hao Gu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Fei-Fen Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Wen-Xiu Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yuan-Yuan Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jiang Yuan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jiang Yuan.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zhou, NL., Gu, H., Tang, FF. et al. Biocompatibility of novel carboxylated graphene oxide–glutamic acid complexes. J Mater Sci 48, 7097–7103 (2013). https://doi.org/10.1007/s10853-013-7523-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10853-013-7523-2

Keywords

Search

Navigation