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Investigation of properties and structural characterization of the quercetin inclusion complex with (2-hydroxypropyl)-β-cyclodextrin

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Abstract

Quercetin is a typical plant flavonoid with a wide variety of pharmacological activities, including anti-inflammatory, anti-oxidative, anti-cancer and anti-age activity. It can be used for treatment of cardiovascular disorders. However, the application of quercetin in pharmacy is limited because of its poor aqueous solubility, low bioavailability, low permeability and instability. In order to overcome the mentioned limitations, an inclusion complex of quercetin with (2-hydroxypropyl)-β-cyclodextrin in a molar ratio of 1:1 have been prepared at room temperature by co-precipitation from ethanol solution. The inclusion complex was prepared at room temperature for 24 h by the co-precipitation method from ethanol solution. The obtained complex were evaporated and dried before the structural characterization. Based on the obtained results of FT-IR, DSC, 1H-NMR and XRD analysis, it can be concluded that the inclusion complex was formed by establishing the interaction between quercetin and (2-hydroxypropyl)-β-cyclodextrin. The phase solubility study indicates that the complexation of quercetin leads to increase the solubility of quercetin in water about 129-fold in the aqueous solution of HP-β-CD (10 mmol dm−3). Also, the photostability of quercetin was improved after its complexation with this cyclodextrin.

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Acknowledgments

This work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia under the project TRp-34012.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Faculty of Technology, University of Nis, Bulevar oslobodjenja 124, 16000, Leskovac, Serbia

    Ivan M. Savic, Vesna D. Nikolic, Ivana Savic-Gajic & Ljubisa B. Nikolic

  2. Faculty of Natural Sciences and Mathematics, University of Nis, Visegradska 33, 18000, Nis, Serbia

    Blaga C. Radovanovic & Jelena D. Mladenovic

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  1. Ivan M. Savic
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  2. Vesna D. Nikolic
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  3. Ivana Savic-Gajic
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Savic, I.M., Nikolic, V.D., Savic-Gajic, I. et al. Investigation of properties and structural characterization of the quercetin inclusion complex with (2-hydroxypropyl)-β-cyclodextrin. J Incl Phenom Macrocycl Chem 82, 383–394 (2015). https://doi.org/10.1007/s10847-015-0500-4

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  • DOI: https://doi.org/10.1007/s10847-015-0500-4

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