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RETRACTED ARTICLE: Can fresh embryo transfers be replaced by cryopreserved-thawed embryo transfers in assisted reproductive cycles? A randomized controlled trial

  • Assisted Reproduction
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

This article was retracted on 23 August 2013

Abstract

Purpose

Controlled ovarian hyperstimulation has been shown to advance endometrial maturation and adversely affects implantation in ART. It has been reported that there is a better embryo-endometrium synchrony in frozen-thawed embryo transfer cycles than fresh embryo transfer cycles. The objective of this study was to compare ongoing pregnancy rates between fresh ET and FET cycles.

Methods

In an open prospective, controlled study, the patients who were classified as high responders, were randomized to either fresh ET or FET. The embryos in FET group were cryopreserved with vitrification by Cryotop method.

Results

A total of 374 patients were included, 187 of which were randomized to FET and 187 to fresh ET. There were 39% (n = 73) ongoing pregnancy in FET group compared with 27.8% (n = 52) in fresh ET group[odds ratio = 1.66;95% confidence interval = 1.07–2.56; p = 0.02].

Conclusions

FETs can be performed instead of fresh ETs to improve the outcome of ART in highly selected patients.

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Acknowledgements

The authors are grateful to the nursing and embryology staff of the Yazd Research and Clinical Center for Infertility and Madar Hospital for their assistance.

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Authors and Affiliations

  1. Research and Clinical Center for Infertility, Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Science, Bouali Ave, Safaieh, 8916877391, Yazd, Iran

    Abbas Aflatoonian, Homa Oskouian, Shahnaz Ahmadi & Leila Oskouian

Authors
  1. Abbas Aflatoonian
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  2. Homa Oskouian
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  3. Shahnaz Ahmadi
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  4. Leila Oskouian
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Corresponding author

Correspondence to Homa Oskouian.

Additional information

Capsule

The implantation and ongoing pregnancy rates are higher in frozen-thawed embryo transfer using vitrification than fresh embryo transfer cycles.

Clinicaltrials.gov Trials registration number NCT00823121.

This article has been retracted at the request of the Editor and the ASRM Publications Committee, based on the results of an investigation which found serious methodological flaws in the study.

The retraction note to this article can be found online at http://dx.doi.org/10.1007/s10815-013-0084-0.

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Aflatoonian, A., Oskouian, H., Ahmadi, S. et al. RETRACTED ARTICLE: Can fresh embryo transfers be replaced by cryopreserved-thawed embryo transfers in assisted reproductive cycles? A randomized controlled trial. J Assist Reprod Genet 27, 357–363 (2010). https://doi.org/10.1007/s10815-010-9412-9

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  • DOI: https://doi.org/10.1007/s10815-010-9412-9

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