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Apolipoprotein E gene polymorphism and polycystic ovary syndrome patients in Western Anatolia, Turkey

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Abstract

Purpose

Dyslipidemia, cardiovascular disease and hypertension are more frequently seen in patients with PCOS than in normal patients. We aimed at evaluating the distribution of Apo E alleles that can influence cardiovascular risk of the PCOS patients and control subjects.

Methods

In this study, 129 young women with PCOS and 91 healthy women were included. In all subjects we performed hormonal, biochemical and Apo E genetic analysis.

Results

The Apo E3 allele was found at a significantly higher frequency in the PCOS patient group compared with the control group. The Apo E2 allele was found at a significantly higher frequency in the control group compared with the patient group with PCOS.

Conclusions

Although there were genotype and allele differences between control and patient groups in this study, no statistically significant change was determined in lipid and other cardiovascular risk factors in connection with allele and genotype.

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Abbreviations

ApoE:

Apolipoprotein E

PCOS:

polycystic ovary syndrome

BMI:

body mass index

CI:

confidence interval

CV:

coefficient(s) of variation

MLRA:

Multiple Logistic Regression Analysis

CVD:

cardiovascular disease

DHEAS:

dehydroepiandrosterone sulphate

E2 :

17ß-estradiol

Hcy:

homocysteine

17-OHP:

17-hydroxyprogesterone

P:

progesterone

PRL:

prolactin

T:

testosterone

FSH:

follicle stimulating hormone

LH:

luteinizing hormone

HOMA-IR:

homeostasis model of assessment insulin resistance

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Acknowledgements

We would like to thank Hatice Uluer for her assistance in statistical evaluation of this study. We are thankful to Technicians of Nail Tartaroglu Endocrinology Laboratory for their assistance in coordinating this study.

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Authors and Affiliations

  1. Division of Internal Medicine, Department of Endocrinology and Metabolism Disease, Ege University Hospital, Izmir, 35100, Turkey

    Sevki Cetinkalp, Muammer Karadeniz, Mehmet Erdogan, Ayhan Zengi, A. Gokhan Ozgen, Fusun Saygili & Candeger Yilmaz

  2. Department of Medical Biology, Ege University Hospital, Izmir, Turkey

    Vildan Cetintas, Aslı Tetik, Zuhal Eroglu & Buket Kosova

Authors
  1. Sevki Cetinkalp
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Correspondence to Muammer Karadeniz.

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Cetinkalp, S., Karadeniz, M., Erdogan, M. et al. Apolipoprotein E gene polymorphism and polycystic ovary syndrome patients in Western Anatolia, Turkey. J Assist Reprod Genet 26, 1–6 (2009). https://doi.org/10.1007/s10815-008-9280-8

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  • DOI: https://doi.org/10.1007/s10815-008-9280-8

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