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4G/5G Polymorphism of PAI-1 gene and Alu-repeat I/D polymorphism of TPA gene in Turkish patients with polycystic ovary syndrome

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Abstract

Purpose

Polycystic ovary syndrome (PCOS) is one of the most encountered endocrine malfunctions. PCOS patients have enhanced activation of the blood coagulation system.

Methods

Eighty-six young women with PCOS and 70 healthy control women were included in our study. PCOS patients and controls were matched for age, body mass index, and allele frequency. Genetic analysis of TPAI and PAI-1 were performed in all subjects.

Results and conclusions

No statistically significant differences have been detected about the ratios of genotypes resulting from PAI-1 promotor 4G/5G gene polymorphism. PAI-1 765 4G/5G gene polymorphism and TPA gene’s Alu-repeat insertion/deletion (I/D) polymorphism ratios were not different from the controls. In this study it is shown by the analysis of TPA gene’s Alu-repeat insertion/deletion (I/D) polymorphism the PCOS patients with genotype II had lowers total cholesterol and LDL-cholesterol levels.

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Authors and Affiliations

  1. Endocrinology and Metabolism Disease, Ege University Hospital, 35100, Bornova, Izmir, Turkey

    Muammer Karadeniz, Mehmet Erdogan, Fusun Saygili & Candeger Yilmaz

  2. Department of Molecular Medicine, Ege University Hospital, Izmir, Turkey

    Afig Berdeli

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  1. Muammer Karadeniz
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  2. Mehmet Erdogan
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  3. Afig Berdeli
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Correspondence to Muammer Karadeniz.

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Karadeniz, M., Erdogan, M., Berdeli, A. et al. 4G/5G Polymorphism of PAI-1 gene and Alu-repeat I/D polymorphism of TPA gene in Turkish patients with polycystic ovary syndrome. J Assist Reprod Genet 24, 412–418 (2007). https://doi.org/10.1007/s10815-007-9160-7

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