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Protective effect of fucoidans from tropical seaweeds against oxidative stress in HepG2 cells

  • 22ND INTERNATIONAL SEAWEED SYMPOSIUM, COPENHAGEN
  • Published:
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Abstract

Fucoidans are sulfated polysaccharides with proven pharmacological effects localized in the cell wall of marine brown algae. The majority of studies have been performed with temperate brown algal species, but in recent years, the evaluation of species from tropical areas has been growing. The aim of this study was to determine the protective effect of fucoidans extracted from the tropical brown seaweeds Dictyota ciliolata, Padina sanctae-crucis, and Sargassum fluitans, against oxidative stress (OS). The D. ciliolata fucoidan (FDc) exhibited the highest reactive oxygen species (ROS) scavenging activity (26%), followed by P. sanctae-crucis fucoidan (FPs) (22%) and S. fluitans fucoidan (FSf) (14%). No cytotoxic effect was detected for any of the extracted fucoidans at a concentration of 2 mg mL−1. Not only did the fucoidans tested show protective effect against OS by reducing ROS generation, but they also increased the glutathione (GSH) level and restored catalase (CAT) activity. Fucoidans obtained from tropical seaweeds could be used as a potential natural ingredient for functional foods.

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Acknowledgments

We wish to thank CONACyT PDC PN 2014 (248004) for funding this project. The authors want to express their acknowledgment to Dr. José Luis Godínez (IB-UNAM) for seaweed species identification and C. Chávez Quintal (CINVESTAV) and R. Pérez Cabeza de Vaca (IF305 UNAM) for their technical assistance during analysis. We also thank Foundation IMSS for the grant received by Rosa Esther Moo-Puc.

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Authors and Affiliations

  1. Unidad de Investigación Médica Yucatán, Unidad Medica de Alta Especialidad (UMAE), Centro Médico Ignacio García Téllez, Instituto Mexicano del Seguro Social (IMSS), Calle 41 No 439 x 32 y 34, Col. Industrial, CP 97150, Mérida, Yucatán, Mexico

    Juan Chale-Dzul & Rosa Moo-Puc

  2. Department of Marine Resources, CINVESTAV Unidad Mérida, Km 6 Carretera Antigua a Progreso, A.P. 73 Cordemex, 97310, Mérida, Yucatán, Mexico

    Juan Chale-Dzul, Yolanda Freile-Pelegrín & Daniel Robledo

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  1. Juan Chale-Dzul
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  2. Yolanda Freile-Pelegrín
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  3. Daniel Robledo
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  4. Rosa Moo-Puc
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Correspondence to Rosa Moo-Puc.

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Chale-Dzul, J., Freile-Pelegrín, Y., Robledo, D. et al. Protective effect of fucoidans from tropical seaweeds against oxidative stress in HepG2 cells. J Appl Phycol 29, 2229–2238 (2017). https://doi.org/10.1007/s10811-017-1194-3

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  • DOI: https://doi.org/10.1007/s10811-017-1194-3

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