Abstract
Diabetic nephropathy (DN) is a type of serious microangiopathy that is caused by diabetes mellitus (DM). It is the most common cause of chronic renal failure and end-stage renal disease, and it severely affects patients’ quality of life. This work aims to study the effect and mechanism of low molecular weight fucoidan (LMWF) on streptozotocin (STZ)-induced DN. The experimental results showed that LMWF prevented weight loss in DN rats, significantly reduced the levels of biochemical indexes in blood and urine samples, and also lowered hyaluronic acid (HA) levels and advanced glycosylation end product-specific receptor (AGER) levels in DN rats. LMWF maintained the structural integrity of glomerular basement membrane (GBM) and glomerulus, improved the glomerular filtration function, protected glycosaminoglycan from abnormal degrading, prevented advanced glycosylation end product (AGE) from being generated and accumulating, and also alleviated inflammatory response in DN rats. LMWF could obviously ameliorate and slow the development and progression of DN in rats.
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Acknowledgments
This work was supported by Natural Science Foundation of China (No. 41376166), The Scientific and Technological Innovation Project Financially Supported by Qingdao National Laboratory for Marine Science and Technology (No. 2015ASKJ02), The Science and Technology Development Project of Shandong Province (No. 2014GHY115017), Special Fund for Marine Scientific Research in the Public Interest (201405040), and Special Found for Marine Scientific Research in Huangdao District (2014-04-11). And we thanked the anonymous reviewers.
Author contributions
Yingjie Xu designed the study, provided most of the data, and wrote the article; Quanbin Zhang co-authored the article and designed the study; Jing Wang co-did the experiments and provided some data; and Dali Luo and Delin Duan co-designed the study.
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Experiments involving live animals were conducted in accordance with the “National Guide for the Care and Use of Laboratory Animals” and the “Regulations for the Administration of Affairs Concerning Experimental Animals” promulgated by the State Science and Technology Commission of Shandong Province. The study was approved by the ethics committee of Institute of Oceanology, Chinese Academy of Sciences.
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Xu, Y., Zhang, Q., Luo, D. et al. Low molecular weight fucoidan ameliorates the inflammation and glomerular filtration function of diabetic nephropathy. J Appl Phycol 29, 531–542 (2017). https://doi.org/10.1007/s10811-016-0942-0
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DOI: https://doi.org/10.1007/s10811-016-0942-0