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Short-term changes in posterior vitreous cortex following intravitreal ocriplasmin for symptomatic vitreomacular traction syndrome: a prospective study

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Abstract

Purpose

To describe and analyze short-term posterior vitreous abnormalities following intravitreal ocriplasmin in eyes with symptomatic vitreomacular traction syndrome (VMT).

Methods

In this institutional, prospective and interventional study enrolled patients with symptomatic focal VMT syndrome treated with intravitreal ocriplasmin. In all cases, spectral-domain optical coherence tomography scans were quantitatively and qualitatively analyzed preoperatively and at 1 and 4 weeks postoperatively.

Results

Twenty-three patients, of which 5 were males and 18 females, with a mean age of 69.5 ± 8.2 years were included in this study. Postoperatively, VMT resolved in 11 of 23 eyes (47.8%). In 9 out of 11 cases (81.8%), VMT resolved by postoperative week 1, whether in the remaining 2 (18.2%) anatomical restoration, was diagnosed at postoperative week 4. At postoperative week 1, a foveolar detachment was detected in 9 out of 23 eyes (39.1%). The foveolar detachment resolved all but one eye by the end of postoperative week 4. At the end of the follow-up period, the presence of subretinal fluid was detected in 7 out of 9 eyes (77.8%), and it was significantly associated with a shrinkage of the posterior vitreous cortex (p < 0.006). At the end of the follow-up period, visual acuity was significantly higher in those eyes with VMT resolution (p < 0.001).

Conclusion

Intravitreal ocriplasmin is effective for the treatment of patients with VMT. The postoperative presence of posterior hyaloid shrinkage may be associated with higher traction over the foveal area and the appearance of foveolar detachment.

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Acknowledgements

The research for this paper was financially supported by Ministry of Health and Fondazione Roma.

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Authors and Affiliations

  1. IRCCS - Fondazione Bietti, Via Livenza 3/5, 00198, Rome, Italy

    Andrea Cacciamani, Roberto Gattegna, Pamela Cosimi & Fabio Scarinci

  2. Azienda Ospedaliera San Giovanni-Addolorata, Rome, Italy

    Marco Pileri & Sara Bardanzellu

  3. Department of Medical, Oral and Biotechnological Sciences, Laboratory of Biostatistics, “G. D’Annunzio” University, Chieti, Italy

    Marta Di Nicola

  4. SDO- Studio di Diagnosi Oculare, Rome, Italy

    Giuliana Facciolo

  5. Ophthalmology Department, Fatebenefratelli-Oftalmico Hospital, ASST-Fatebenefratelli-Sacco, Milan, Italy

    Andrea Govetto

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  1. Andrea Cacciamani
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  2. Roberto Gattegna
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  4. Marta Di Nicola
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  7. Pamela Cosimi
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  8. Andrea Govetto
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  9. Fabio Scarinci
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Correspondence to Fabio Scarinci.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Cacciamani, A., Gattegna, R., Pileri, M. et al. Short-term changes in posterior vitreous cortex following intravitreal ocriplasmin for symptomatic vitreomacular traction syndrome: a prospective study. Int Ophthalmol 40, 185–193 (2020). https://doi.org/10.1007/s10792-019-01177-7

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  • DOI: https://doi.org/10.1007/s10792-019-01177-7

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