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Novel approaches to the post-myocardial infarction/heart failure neural remodeling

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Abstract

The review aims to discuss the role of nerve growth factor (NGF) as a potential novel biomarker in post-myocardial infarction (MI) and in heart failure (HF), with a specific focus on neural remodeling and sprouting processes occurring after tissue damage. Many experimental data show that MI induces nerve sprouting, leading to increased sympathetic outflow and higher risk of ventricular arrhythmias and sudden cardiac death. In this framework, cardiac and circulating NGF might be an indicator of the innervation process and neural remodeling: it dramatically increases after MI, while it declines along with advanced HF and ventricular dysfunction. The bimodal behavior of NGF in acute and chronic settings leads to the speculation that NGF modulation may be a pharmacological target for intervention in different stages of the ischemic heart disease. Specifically, a fascinating possibility is to support or to inhibit NGF receptors, in order to prevent negative cardiac remodeling after MI and consequent ventricular dysfunction.

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Conflict of interest

Dr E. D’Elia, Dr Alessia Pasale, Dr Nicoletta Marchesi, Dr Paolo Ferrero, Dr Michele Senni, Dr Stefano Govoni, Dr Edoardo Gronda e Dr Emilio Vanoli have no conflicts of interest or financial ties to disclose.

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Authors and Affiliations

  1. Cardiovascular Department, Azienda Ospedaliera Papa Giovanni XXIII, Piazza OMS 1, 24120, Bergamo, Italy

    Emilia D’Elia, Paolo Ferrero & Michele Senni

  2. Department of Drug Sciences, Pharmacology Section, University of Pavia, Pavia, Italy

    Alessia Pascale, Nicoletta Marchesi & Stefano Govoni

  3. Cardiovascular Department, Policlinico San Matteo, University of Pavia, Pavia, Italy

    Emilio Vanoli

  4. Cardiovascular Department, Multimedica IRCCS, Sesto San Giovanni, Italy

    Edoardo Gronda & Emilio Vanoli

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  1. Emilia D’Elia
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  2. Alessia Pascale
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Correspondence to Emilia D’Elia.

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D’Elia, E., Pascale, A., Marchesi, N. et al. Novel approaches to the post-myocardial infarction/heart failure neural remodeling. Heart Fail Rev 19, 611–619 (2014). https://doi.org/10.1007/s10741-013-9415-6

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