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Cytotoxic activities of new iron(III) and nickel(II) chelates of some S-methyl-thiosemicarbazones on K562 and ECV304 cells

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Summary

The S-methyl-thiosemicarbazones of the 2-hydroxy-R-benzaldehyde (R= H, 3-OH 3-OCH3 or 4-OCH3) reacted with the corresponding aldehydes in the presence of FeCl3 and NiCl2. New ONNO chelates of iron(III) and nickel(II) with hydroxy- or methoxy-substitued N 1,N 4-diarylidene-S-methyl-thiosemicarbazones were characterized by means of elemental analysis, conductivity and magnetic measurements, UV-Vis, IR and 1H-NMR spectroscopies. Cytotoxic activities of the compounds were determined using K562 chronic myeloid leukemia and ECV304 human endothelial cell lines by MTT assay. It was determined that monochloro N 1-4-methoxysalicylidene-N 4-4-methoxysalicylidene-S-methyl-thiosemicarbazidato-iron(III) complex showed selective anti-leukemic effects in K562 cells while has no effect in ECV304 cells in the 0.53 μg/ml (IC50) concentrations. Also, some methoxy-substitued nickel(II) chelates exhibit high cytotoxic activitiy against both of these cell lines in low concentrations. Cytotoxicity data were evaluated depending on cell lines origin and position of the substituents on aromatic rings.

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Acknowledgement

This work was supported by the Research Fund of Istanbul University. Project number, 516/05052006.

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Authors and Affiliations

  1. Faculty of Engineering and Natural Sciences, Sabanci University, 34956, Tuzla, Istanbul, Türkiye

    Belkıs Atasever

  2. Department of Chemistry, Istanbul University, 34320, Avcilar, Istanbul, Türkiye

    Bahri Ülküseven & Tülay Bal-Demirci

  3. Physiology Department, Istanbul Medical Faculty, Istanbul University, Istanbul, Türkiye

    Serap Erdem-Kuruca & Zeynep Solakoğlu

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  1. Belkıs Atasever
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Correspondence to Tülay Bal-Demirci.

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Atasever, B., Ülküseven, B., Bal-Demirci, T. et al. Cytotoxic activities of new iron(III) and nickel(II) chelates of some S-methyl-thiosemicarbazones on K562 and ECV304 cells. Invest New Drugs 28, 421–432 (2010). https://doi.org/10.1007/s10637-009-9272-2

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