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Factors Predisposing Metastatic Tumor Antigen 1 Overexpression in Hepatitis B Virus Associated Hepatocellular Carcinoma

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Abstract

Background/Aim

Overexpression of metastatic tumor antigen-1 (MTA-1) is suggested to be associated with frequent postoperative recurrence and poor survival of hepatocellular carcinoma (HCC) patients. In this study, we intended to determine clinical factors predisposing the overexpression of MTA-1 in patients with hepatitis B virus (HBV)-associated HCC and also examine whether MTA-1 overexpression affects the survival periods of these patients treated with curative surgical resection.

Methods

A total of 303 patients with HBV-associated HCC who underwent curative surgical resection were subjected. The expressions of MTA-1 in HCC and surrounding non-tumor liver tissues were evaluated using the immunohistochemical method. The clinical, radiological and histological characteristics of the patients were analyzed in relation to the expression of MTA-1 to find predisposing factors of MTA-1 overexpression.

Results

MTA-1 was overexpressed in 104 HCC tissues (34.3 %) and none of the surrounding non-tumor tissues. Clinically, MTA-1 overexpression was significantly associated with younger age, female gender, higher serum alpha-fetoprotein level, and Child–Turcotte–Pugh class A. Also, portal vein thrombosis, microvascular invasion, capsular invasion and poorly histological differentiation were associated with overexpression of MTA-1. The cumulative survival rates were significantly lower in patients with MTA-1 overexpression compared with those in the MTA-1 negative group (P = 0.03). In addition to the overexpression of MTA-1, the presence of microvascular or capsular invasion was a significant factor determining the poor survival of the patients with HBV-associated HCC after curative resection.

Conclusions

MTA-1 is overexpressed in patients with HBV-associated HCC of invasive nature. MTA-1 overexpression is associated with shorter survival periods of patients with HBV-associated HCC after curative resection.

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Abbreviations

AFP:

Alpha-fetoprotein

CTP:

Child-Turcotte-Pugh

CT:

Computed tomography

E–S:

Edmondson–Steiner

HBV:

Hepatitis B virus

HCC:

Hepatocellular carcinoma

HCV:

Hepatitis C virus

HIF:

Hypoxia inducible factor

HR:

Hazard ratio

MTA-1:

Metastatic tumor antigen-1

NuRD:

Nucleosome remodeling and histone deacetylation

PVT:

Portal vein thrombosis

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Authors and Affiliations

  1. Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Korea

    Young-Joo Jin, Young-Hwa Chung, Jeong A. Kim, Won Hyung Park & Danbi Lee

  2. Department of Internal Medicine, Sanggye Paik Hospital, University of Inje College of Medicine, Seoul, Korea

    Dong Dae Seo

  3. Department of Internal Medicine, Seoul Paik Hospital, University of Inje College of Medicine, Seoul, Korea

    Soo Hyung Ryu

  4. Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea

    Myoung Kuk Jang

  5. Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

    Eunsil Yu

  6. Department of Hepatobiliary Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

    Young Joo Lee

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  1. Young-Joo Jin
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Correspondence to Young-Hwa Chung.

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Jin, YJ., Chung, YH., Kim, J.A. et al. Factors Predisposing Metastatic Tumor Antigen 1 Overexpression in Hepatitis B Virus Associated Hepatocellular Carcinoma. Dig Dis Sci 57, 2917–2923 (2012). https://doi.org/10.1007/s10620-012-2296-z

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  • DOI: https://doi.org/10.1007/s10620-012-2296-z

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