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Inhibitory Effects of Fermented Brown Rice on Induction of Acute Colitis by Dextran Sulfate Sodium in Rats

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Abstract

Although the pathogenic mechanisms of inflammatory bowel diseases are not fully understood, colonic microbiota may affect the induction of colonic inflammation, and some probiotics and prebiotics have been reported to suppress colitis. The inhibitory effects of brown rice fermented by Aspergillus oryzae (FBRA), a fiber-rich food, on the induction of acute colitis by dextran sulfate sodium (DSS) were examined. Feeding a 5% and 10% FBRA-containing diet significantly decreased the ulcer and erosion area in the rat colon stained with Alcian blue. In another experiment, 10% FBRA feeding decreased the ulcer index (percentage of the total length of ulcers in the full length of the colon) and colitis score, which were determined by macroscopic observation. It also decreased myeloperoxidase activity in the colonic mucosa. Viable cell numbers of Lactobacillus in the feces decreased after DSS administration and was reversely correlated with severity of colitis, while the cell number of Enterobacteriaceae increased after DSS treatment and was positively correlated with colitis severity. These results indicate that FBRA has a suppressive effect on the induction of colitis by DSS and suggest FBRA-mediated modification of colonic microbiota.

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Authors and Affiliations

  1. Department of Molecular Bacteriology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, 770-8503, Japan

    Keiko Kataoka, Sachiko Ogasa, Tomomi Kuwahara, Mari Hagiwara, Hideki Arimochi, Shuusuke Nakanishi & Yoshinari Ohnishi

  2. Department of Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, 770-8503, Japan

    Yoshimi Bando

  3. Genmai Koso Co., Ltd, Nishi 1-chome, Kita-ku, Sapporo, 001-0012, Japan

    Teruaki Iwasaki

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  1. Keiko Kataoka
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Correspondence to Keiko Kataoka.

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Kataoka, K., Ogasa, S., Kuwahara, T. et al. Inhibitory Effects of Fermented Brown Rice on Induction of Acute Colitis by Dextran Sulfate Sodium in Rats. Dig Dis Sci 53, 1601–1608 (2008). https://doi.org/10.1007/s10620-007-0063-3

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  • DOI: https://doi.org/10.1007/s10620-007-0063-3

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