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A New Flavone and Cytotoxic Constituents of Nicotiana tabacum

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A new flavone, 8-formyl-7-hydroxy-6,4′-dimethoxyflavone (1), has been isolated from the leaves of Nicotiana tabacum, together with five known compounds, 8-formyl-4′-hydroxy-6,7-dimethoxyflavone (2), quercetin (3), (2R,3R)-3,5-dihydroxy-7-methoxyflavanone (4), kaempferol (5), and rutin (6). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, 8-formyl-7-hydroxy-6,4′-dimethoxyflavone (1) and 8-formyl-4′-hydroxy-6,7-dimethoxyflavone (2) exhibited cytotoxicities, with IC50 values of 2.24 ± 0.32 and 3.40 ± 0.21 μg/mL, respectively, against CCRF-CEM and P388D1 cell lines.

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Acknowledgment

This research was supported by a grant from Ministry of Science and Technology, Taiwan (MOST 105-2320-B-010-040), awarded to Prof. J.-J. Chen. This work was also supported by the grants from Zuoying Branch of Kaohsiung Armed Forces General Hospital (ZBH 106-25) and Pingtung Christian Hospital (PS 106022). Sheng-Kan Chien, Lih-Chi Chen, Hui-Chu Huang, Li-Chai Chen, and Jen-Wen Hsiao have contributed equally in this manuscript.

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Authors and Affiliations

  1. Department of Pharmacy, Keelung City Municipal Hospital, 202, Keelung, Taiwan

    Sheng-Kan Chien

  2. Department of Pharmacy, Taipei City Hospital, 108, Taipei, Taiwan

    Lih-Chi Chen

  3. Department of Pharmacy, Tajen University, 907, Pingtung, Taiwan

    Lih-Chi Chen & Li-Chai Chen

  4. Center for General Education, National United University, 360, Miaoli, Taiwan

    Lih-Chi Chen

  5. Department of Respiratory Care, Zuoying Branch of Kaohsiung Armed Forces General Hospital, 813, Kaohsiung, Taiwan

    Hui-Chu Huang

  6. Department of Pharmacy, Zuoying Branch of Kaohsiung Armed Forces General Hospital, 813, Kaohsiung, Taiwan

    Li-Chai Chen

  7. Department of Pharmacy, Pingtung Christian Hospital, 900, Pingtung, Taiwan

    Jen-Wen Hsiao

  8. Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), 300, Hsinchu, Taiwan

    Ming-Jen Cheng

  9. Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, 112, Taipei, Taiwan

    Jih-Jung Chen

  10. Department of Medical Research, China Medical University Hospital, 404, Taichung, Taiwan

    Jih-Jung Chen

Authors
  1. Sheng-Kan Chien
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  2. Lih-Chi Chen
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  3. Hui-Chu Huang
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  4. Li-Chai Chen
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  5. Jen-Wen Hsiao
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  6. Ming-Jen Cheng
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  7. Jih-Jung Chen
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Corresponding author

Correspondence to Jih-Jung Chen.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2018, pp. 888–890.

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Chien, SK., Chen, LC., Huang, HC. et al. A New Flavone and Cytotoxic Constituents of Nicotiana tabacum. Chem Nat Compd 54, 1044–1047 (2018). https://doi.org/10.1007/s10600-018-2551-4

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  • DOI: https://doi.org/10.1007/s10600-018-2551-4

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