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Bioactive flavonoids from Flos Sophorae

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Abstract

Three new flavonoid glycosides—soyaflavonosides A (1), B (2), and C (3)—together with 23 known ones were obtained from the 70% EtOH extract of Flos Sophorae (Sophora japonica, Leguminosae). Their structures were elucidated by chemical and spectroscopic methods. Among the known isolates, 14, 18, 20, 22, and 26 were isolated from the Sophora genus for the first time; 12, 19, 24, and 25 were obtained from the species firstly. Moreover, NMR data for compounds 18 and 26 are reported for the first time here. Meanwhile, compounds 4, 8–13, 15, 16, 19, 21, and 22 presented obvious inhibitory effects on TG accumulation in HepG2 cells. Analysis of the structure–activity relationship indicated that all of the quercetin glycosides examined in this study possess significant activity that is not significantly influenced by the amount of glycosyl present, whereas increasing the amount of glycosyl reduced the activities of isorhamnetin glycosides and orobol. In addition, a high dose (30 μmol/l) of kaempferol was found to inhibit HepG2 cell growth, while a low dose (10 μmol/l) was observed to decrease TG accumulation.

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Acknowledgements

This work was financially supported by grants from the National Natural Science Foundation of China (NSFC 81673703) and the program for Changjiang Scholars and Innovative Research Team in University (PCSIRT IRT_14R41).

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Authors and Affiliations

  1. Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin, 300193, China

    Wenzhong Shi, Lili Liu, Haiyang Yu, Yi Zhang & Tao Wang

  2. Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin, 300193, China

    Jian Li, Lu Qu, Xu Pang, Haiyang Yu, Yi Zhang & Tao Wang

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  1. Wenzhong Shi
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  2. Lili Liu
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  3. Jian Li
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  4. Lu Qu
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  5. Xu Pang
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  6. Haiyang Yu
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  7. Yi Zhang
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  8. Tao Wang
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Correspondence to Yi Zhang or Tao Wang.

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Shi, W., Liu, L., Li, J. et al. Bioactive flavonoids from Flos Sophorae. J Nat Med 71, 513–522 (2017). https://doi.org/10.1007/s11418-017-1084-7

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  • DOI: https://doi.org/10.1007/s11418-017-1084-7

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