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Acidic ionic liquids: highly efficient catalysts for one-pot four-component synthesis of pyrazolo[1,2-b]phthalazines under solvent-free conditions

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Chemistry of Heterocyclic Compounds Aims and scope

A series of novel pyrazolo[1,2-b]phthalazine-2-carboxylate derivatives has been synthesized via one-pot four-component reaction of aromatic aldehyde, ethyl or methyl acetoacetate, hydrazine hydrate, and phthalic anhydride in the presence of acidic ionic liquids such as 3-methyl-1-sulfo-1H-imidazol-3-ium chloride, 1,3-disulfo-1H-imidazol-3-ium chloride, and triethyl(sulfo)ammonium chloride as the catalyst. This method involves particular advantages such as environmentally benign catalysts, high yields of product, reusability of ionic liquids with high activity, short reaction times, no hazardous solvent, and easy workup.

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Authors and Affiliations

  1. Department of Chemistry, Shahid Bahonar University of Kerman, Kerman, 76169, Iran

    Behjat Pouramiri

  2. Department of Chemistry, Islamic Azad University of Kerman, Kerman, 7635131167, Iran

    Reza Ghahramani Far

  3. Department of Chemistry, Faculty of Science, University of Jiroft, Jiroft, 7867161167, Iran

    Mahboobeh Zahedifar

Authors
  1. Behjat Pouramiri
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  2. Reza Ghahramani Far
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  3. Mahboobeh Zahedifar
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Corresponding author

Correspondence to Mahboobeh Zahedifar.

Additional information

Supplementary information file containing Table S1, Table S2, 1H, 13C NMR, and mass spectra of the new compounds is available at the journal website at http://link.springer.com/journal/10593.

Published in Khimiya Geterotsiklicheskikh Soedinenii, 2018, 54(11), 1056–1060

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Pouramiri, B., Far, R.G. & Zahedifar, M. Acidic ionic liquids: highly efficient catalysts for one-pot four-component synthesis of pyrazolo[1,2-b]phthalazines under solvent-free conditions. Chem Heterocycl Comp 54, 1056–1060 (2018). https://doi.org/10.1007/s10593-018-2391-y

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  • DOI: https://doi.org/10.1007/s10593-018-2391-y

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